Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis

BMJ : British Medical Journal
Xiaoyan CaiYuli Huang

Abstract

To evaluate the associations between prediabetes and the risk of all cause mortality and incident cardiovascular disease in the general population and in patients with a history of atherosclerotic cardiovascular disease. Updated meta-analysis. Electronic databases (PubMed, Embase, and Google Scholar) up to 25 April 2020. Prospective cohort studies or post hoc analysis of clinical trials were included for analysis if they reported adjusted relative risks, odds ratios, or hazard ratios of all cause mortality or cardiovascular disease for prediabetes compared with normoglycaemia. Data were extracted independently by two investigators. Random effects models were used to calculate the relative risks and 95% confidence intervals. The primary outcomes were all cause mortality and composite cardiovascular disease. The secondary outcomes were the risk of coronary heart disease and stroke. A total of 129 studies were included, involving 10 069 955 individuals for analysis. In the general population, prediabetes was associated with an increased risk of all cause mortality (relative risk 1.13, 95% confidence interval 1.10 to 1.17), composite cardiovascular disease (1.15, 1.11 to 1.18), coronary heart disease (1.16, 1.11 to 1.21), and strok...Continue Reading

References

Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Apr 18, 2001·American Journal of Preventive Medicine·R P HarrisUNKNOWN Methods Work Group, Third US Preventive Services Task Force
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Oct 2, 2007·The American Journal of Medicine·Seth UretskyCarl J Pepine
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
Jun 12, 2012·Lancet·Adam G TabákMika Kivimäki
Sep 17, 2013·Current Diabetes Reports·Elias K Spanakis, Sherita Hill Golden
Dec 21, 2013·Diabetes Research and Clinical Practice·W M AdmiraalI G M van Valkengoed
Nov 22, 2014·Diabetes Care·William T CefaluRobert E Ratner
Feb 12, 2015·Current Diabetes Reviews·Matthew J L Hare, Jonathan E Shaw
Apr 17, 2016·International Journal of Cardiology·Min LiZhen-Yu Tang
Nov 20, 2016·The Lancet. Diabetes & Endocrinology·Lydia E Makaroff
Mar 5, 2017·Stroke; a Journal of Cerebral Circulation·Nam Hoon KimSin Gon Kim
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Aug 7, 2017·The Lancet. Diabetes & Endocrinology·Prashanth R J VasMichael E Edmonds
Aug 16, 2017·Journal of the American Pharmacists Association : JAPhA·Nicholas W CarrisWilliam N Kelly
Sep 11, 2018·Expert Opinion on Pharmacotherapy·Aisling ManganWerd Al-Najim
Mar 9, 2019·Science·Charles Piller
May 1, 2019·The Lancet. Diabetes & Endocrinology·Qiuhong GongUNKNOWN Da Qing Diabetes Prevention Study Group
Sep 10, 2019·European Heart Journal·Francesco CosentinoUNKNOWN ESC Scientific Document Group
Nov 27, 2019·European Journal of Preventive Cardiology·Jwj BeulensR C Vos
Nov 30, 2019·Diabetes Care·Olive TangElizabeth Selvin
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Jan 16, 2021·Journal of General Internal Medicine·Sidra L SpeakerMichael B Rothberg
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ram JagannathanMichael Bergman
Nov 14, 2020·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Naomi N Duke
Jan 15, 2021·Diabetes Care·Zobida IslamUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group
Mar 2, 2021·Frontiers in Cardiovascular Medicine·Qingchun ZengDingli Xu
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Jing CuiYue Liu
Mar 27, 2021·Diabetes, Obesity & Metabolism·Xiaoyan CaiYuli Huang
May 1, 2021·International Journal of Molecular Sciences·Yin LiangKen Takahashi
Jun 5, 2021·Journal of the American College of Cardiology·Raul D SantosChristie M Ballantyne
May 26, 2021·Cardiovascular Diabetology·Jian-di WuYue Xie
Jun 4, 2021·Diabetes Research and Clinical Practice·Teresa Vanessa FiorentinoGiorgio Sesti
Jun 1, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ferdinando Carlo SassoLuca Rinaldi
Jun 26, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Volker H SchmittThomas Münzel
Jun 6, 2021·The Journal of Clinical Endocrinology and Metabolism·Qi LuGang Liu
Jul 3, 2021·International Journal of Molecular Sciences·Elena BarbuSerban-Mihai Balanescu
Jul 13, 2021·Therapeutic Advances in Chronic Disease·Xiaoyan CaiYuli Huang
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Zhuo-Ming HuangZhuo-Wen Huang
Jul 16, 2021·Science Progress·Emile AndariMurad Al-Naqshbandi
Jul 21, 2021·Current Medical Research and Opinion·Ulrike Hostalek, Ian Campbell
May 21, 2021·Journal of the American College of Cardiology·Michael C HonigbergMuthiah Vaduganathan
Jul 7, 2021·Diabetes, Obesity & Metabolism·Linlin MaiYuli Huang
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Stephen Colagiuri
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Daisy DuanJustin B Echouffo-Tcheugui
Aug 26, 2021·Diabetes, Obesity & Metabolism·Thirunavukkarasu SathishJonathan E Shaw
Aug 31, 2021·Frontiers in Cardiovascular Medicine·Haicheng LiYanming Chen
Jul 3, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Julia M GrottenthalerMartina Guthoff
Oct 1, 2021·The Journal of International Medical Research·Hang GongFang Cheng

❮ Previous
Next ❯

Methods Mentioned

BETA
IEC

Software Mentioned

Meta - analysis of Observational Studies in Epidemiology ( MOO...
Stata
RevMan
Google Scholar

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved