Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma

PloS One
Judith SchwartzbaumTom K Grimsrud

Abstract

Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-related serum proteins are associated with glioma, we conducted a nested case-control study of seven cytokines (IL4, IL13, IL5, IL6, IL10, IFNG, TGFB2), two soluble cytokine receptors (sIL4RA, sIL13RA2) and three allergy-related transcription factors (FOXP3, STAT3, STAT6) using serum specimens from the Janus Serum Bank Cohort in Oslo, Norway. Blood donors subsequently diagnosed with glioma (n = 487) were matched to controls (n = 487) on age and date of blood draw and sex. We first estimated individual effects of the 12 serum proteins and then interactions between IL4 and IL13 and their receptors using conditional logistic regression. We next tested equality of case-control inter-correlations among the 12 serum proteins. We found that TGFB2 is inversely related to glioblastoma (Odds Ratio (OR) = 0.87, 95% Confidence Interval (CI)) = 0.76, 0.98). In addition, ≤ 5 years before diagnosis, we observed associations between IL4 (OR = 0.82, 95% CI = 0.66, 1.01), sIL4RA (OR = 0.80, 95% CI = 0.65, 1.00), their interaction (OR = 1.06, 95% CI = 1.01, 1.12) and glioblastoma. This interaction was apparent > 20 years before diagnosis (IL4-sIL4RA OR = 1.20,...Continue Reading

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Citations

May 21, 2017·The Journal of Allergy and Clinical Immunology·Erika Jensen-JarolimSophia N Karagiannis
Jan 18, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M A AltinozI Elmaci
Mar 4, 2018·Journal of Neuro-oncology·Camille PouchieuIsabelle Baldi
Sep 16, 2018·Journal of Clinical Pharmacy and Therapeutics·Rashmi R Shah, Peter D Stonier
Mar 27, 2019·Cancers·Massimo Costanza, Gaetano Finocchiaro
Jun 9, 2017·PloS One·Judith SchwartzbaumTom K Grimsrud
Oct 22, 2020·Antibodies·Jitesh ChauhanHeather J Bax
Mar 6, 2021·The World Allergy Organization Journal·Denisa FerastraoaruErika Jensen-Jarolim

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Methods Mentioned

BETA
Antibody Array
ELISA
blood draw

Software Mentioned

R
SAS
GenePix

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