Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity

Journal of Hypertension
Andrew M SouthLisa K Washburn

Abstract

Preterm birth appears to contribute to early development of cardiovascular disease, but the mechanisms are unknown. Prematurity may result in programming events that alter the renin-angiotensin system. We hypothesized that prematurity is associated with lower angiotensin-(1-7) in adolescence and that sex and obesity modify this relationship. We quantified angiotensin II and angiotensin-(1-7) in the plasma and urine of 175 adolescents born preterm and 51 term-born controls. We used generalized linear models to estimate the association between prematurity and the peptides, controlling for confounding factors and stratifying by sex and overweight/obesity. Prematurity was associated with lower plasma angiotensin II (β: -5.2 pmol/l, 95% CI: -10.3 to -0.04) and angiotensin-(1-7) (-5.2 pmol/l, 95% CI: -8.4 to -2.0) but overall higher angiotensin II:angiotensin-(1-7) (3.0, 95% CI: 0.9-5.0). The preterm-term difference in plasma angiotensin-(1-7) was greater in women (-6.9 pmol/l, 95% CI: -10.7 to -3.1) and individuals with overweight/obesity (-8.0 pmol/l, 95% CI: -12.2 to -3.8). The preterm-term difference in angiotensin II:angiotensin-(1-7) was greater among those with overweight/obesity (4.4, 95% CI: 0.6-8.1). On multivariate analysi...Continue Reading

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Citations

Aug 17, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andrew M SouthLisa K Washburn
Apr 17, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yogavijayan KandasamyRoger Smith
Feb 23, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bonita Falkner
Nov 25, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael FreundlichBernardo Rodriguez-Iturbe
Aug 28, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsin ChiChien-Yu Lin
Feb 12, 2021·Early Human Development·Stefano ForestieriVassilios Fanos
Dec 1, 2020·The Journal of Pediatrics·Andrew M SouthArvind Sehgal
May 20, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·D Clark FilesMark C Chappell
Jul 31, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Coral D Hanevold
Sep 10, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ella C Perrin, Andrew M South

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