Association between pretransplant Thymoglobulin and reduced non-relapse mortality rate after marrow transplantation from unrelated donors

Bone Marrow Transplantation
M RembergerClaudio Anasetti

Abstract

A matched cohort study was designed to test the efficacy of polyclonal rabbit antiserum specific for human T cells (Thymoglobulin), administered in vivo on days 1-5 (2 mg/kg/day) before T cell-replete unrelated donor marrow transplantation. Thymoglobulin was given to 52 leukemic patients at Huddinge Hospital. Control patients matched for diagnosis, disease stage, age and treated with a similar regimen, apart from the omission of Thymoglobulin, were selected in Seattle during the same period (n = 104). All received conditioning with cyclophosphamide and TBI. In the study group all patients received 10 Gy single dose TBI, while the controls were given 12-14.4 Gy fractionated TBI. GVHD prophylaxis was cyclosporine and methotrexate. Patients were treated for grade I acute GVHD in the study group, and for grade II GVHD in the control group. Multivariable analyses were adjusted for patient and donor age and CMV serology, HLA matching, donor gender and marrow cell dose. Non-relapse mortality was lower in the study patients (hazard ratio = 0.30, 95% CI 0.12-0.75, P value = 0.005). The 5-year cumulative incidence of non-relapse mortality was 19% in the study cohort, and 35% in the control cohort. Overall mortality was also lower in stud...Continue Reading

References

Dec 15, 1977·The New England Journal of Medicine·R J O'ReillyR A Good
May 10, 1979·The New England Journal of Medicine·P L WeidenR Storb
Apr 17, 1975·The New England Journal of Medicine·E ThomasC D Buckner
Jan 1, 1992·British Journal of Haematology·M StockschlaederK Sullivan
Mar 7, 1991·The New England Journal of Medicine·J L Ferrara, H J Deeg
Jul 1, 1993·European Journal of Haematology·O Ringdén
Mar 4, 1993·The New England Journal of Medicine·N A KernanJ McCullough
Apr 2, 1998·The New England Journal of Medicine·J A HansenC Anasetti
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T GirinskyJ L Pico
Apr 6, 2000·Current Opinion in Oncology·C AnasettiJ A Hansen

❮ Previous
Next ❯

Citations

Jul 9, 2009·Bone Marrow Transplantation·A BacigalupoUNKNOWN Gruppo Italiano Trapianto Midollo Osseo (GITMO)
Oct 12, 2005·Journal of Pediatric Hematology/oncology·Markus G SeidelChristina Peters
May 23, 2012·Expert Review of Clinical Immunology·Ekapun Karoopongse, H Joachim Deeg
Sep 9, 2009·British Journal of Haematology·Olle RingdénMichael Uhlin
Jan 9, 2008·Seminars in Hematology·A John Barrett, Bipin N Savani
Feb 17, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Olle Ringdén, Katarina Le Blanc
Jun 9, 2006·Blood Reviews·Wendy IngramGhulam J Mufti
Jan 18, 2006·Seminars in Hematology·Nelson J Chao, Benny J Chen
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Emma P Das-GuptaJennifer L Byrne
Aug 6, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hyoung Jin KangUNKNOWN Korean Society of Pediatric Hematology-Oncology
Jan 30, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Olle RingdénMats Remberger
May 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Edoardo LaninoUNKNOWN Franca Fagioli for the AIEOP-HSCT Group
Oct 19, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Amir A ToorMasoud H Manjili
Sep 14, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu WangXiao-Jun Huang
Oct 27, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Scott D RowleyRobert Preti
Apr 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoUNKNOWN Gruppo Italiano Trapianti Midollo Osseo (GITMO)
Apr 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·H Joachim DeegRainer Storb
Aug 30, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christopher N BredesonDouglas A Stewart
Jan 27, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sandra K CallGregory A Hale
Mar 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J F LacerdaJ M F Lacerda
Aug 3, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nobuhiro WatanabeSeiji Kojima
Jan 11, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joseph PidalaClaudio Anasetti
Dec 1, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcel P Devetten, Julie M Vose
Dec 1, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Petter SvenbergOlle Ringdén
Aug 13, 2010·Blood·H Joachim Deeg, Brenda M Sandmaier
Oct 11, 2012·Immunotherapy·Yasser ElboraiLeslie Lehmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.