Association between primary graft dysfunction among lung, kidney and heart recipients from the same multiorgan donor

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Takahiro OtoGregory I Snell

Abstract

Even organs from an ideal donor will occasionally develop primary graft dysfunction (PGD) causing a significant morbidity and mortality after transplantation. It is likely that this situation represents subtle undetectable levels of ongoing donor organ dysfunction. The aim of this study is to investigate the association of PGD between lung, kidney and heart recipients from the one donor. From 202 multiorgan donors, contributed 231 consecutive lung transplants at the Alfred Hospital, 378 kidney and 114 heart transplants were subsequently performed at multiple centers across Australia and New Zealand. Eight hundred seventy-five organs were used for 723 transplants. The incidence of PGD after lung, kidney and heart transplants was 20% (47/231), 24% (92/378) and 20% (23/114), respectively. In paired single organ recipients, PGD in one of the pair was a significant risk factor for the development of PGD in the other [lung: odds ratio = 5.63 (1.72-18.43), p = 0.004; kidney: odds ratio = 3.19 (1.90-5.35), p < 0.0001]. In multivariate analysis, same donor heart PGD [3.37 (1.19-9.50), p = 0.02] was an independent risk factor for lung PGD and same donor lung PGD was significant risk factor for kidney PGD [1.94 (1.01-3.73), p = 0.04], if ...Continue Reading

References

Sep 1, 1996·The Annals of Thoracic Surgery·K E SommersR J Keenan
Feb 11, 1998·Transplantation·W W PfaffA I Reed
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·R OberbauerG Mayer
Nov 15, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G I SnellT J Williams
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S L NybergM D Stegall
Feb 14, 2003·Current Opinion in Urology·Christoph Schwarz, Rainer Oberbauer
Oct 14, 2003·Chest·Jason D ChristieStephen E Kimmel
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·William D IrishMark A Schnitzler
Jan 2, 2004·Transplantation·Jacqueline M A SmitsUNKNOWN Eurotransplant Study on Twin Lung Transplants (ESOTWIN) Study Group
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc de PerrotUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Nov 1, 2005·The Journal of Thoracic and Cardiovascular Surgery·Takahiro OtoGregory I Snell
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Silvana F MarascoMeroula Richardson
Jan 27, 2006·Transplantation·Jonathan A GrossbergPaul E Morrissey
Dec 5, 2006·The Journal of Thoracic and Cardiovascular Surgery·Takahiro OtoGregory I Snell
Dec 23, 2006·The Annals of Thoracic Surgery·Takahiro OtoGregory I Snell
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V S AvlonitisJ H Dark
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S McDonaldS Chadban
Apr 7, 2007·Transplantation·Paul E Morrissey
Apr 24, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Takahiro OtoGregory I Snell
Mar 25, 2008·International Journal of Surgery·David K C Cooper

❮ Previous
Next ❯

Citations

Aug 27, 1990·Biochimica Et Biophysica Acta·P F Miller, A G Hinnebusch
Jan 4, 2012·British Journal of Anaesthesia·D W McKeownJ A Kellum
Mar 17, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Aldo CannataLuigi Martinelli
Aug 13, 2011·Journal of Transplantation·Arjun IyerPeter Simon Macdonald
Apr 23, 2009·American Journal of Respiratory and Critical Care Medicine·Vibha N Lama
Oct 14, 2014·The American Journal of the Medical Sciences·Andres PelaezDavid M Guidot
Apr 23, 2011·Clinics in Chest Medicine·Gregory I Snell, Glen P Westall
May 25, 2010·The Annals of Thoracic Surgery·Tomokazu KakishitaShinichiro Miyoshi
May 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Seyedhossein AharinejadMichael Grimm
Dec 14, 2011·Clinical Transplantation·Silvana F MarascoTrevor Williams
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SalamaS Aharinejad
Mar 26, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference participants
Jul 24, 2010·Journal of the American College of Cardiology·Vamsidhar B DronavalliRobert S Bonser
Jun 9, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Lakshmi Kumar
Mar 21, 2017·Medicina intensiva·C Chamorro-JambrinaM S Pérez-Cornejo
Mar 20, 2018·Current Opinion in Organ Transplantation·Eugene C DePasquale, Abbas Ardehali
Sep 30, 2016·World Journal of Transplantation·Raffaele Girlanda
Jul 22, 2009·Current Opinion in Organ Transplantation·Gregory I Snell, Glen P Westall
Apr 26, 2019·Heart Failure Reviews·Sanjeet Singh Avtaar SinghNawwar Al-Attar
Dec 14, 2019·Clinical Transplantation·Tsuyoshi TakahashiRamsey R Hachem
Dec 9, 2020·The Journal of Clinical Investigation·Daniel R CalabreseJohn R Greenland
Aug 19, 2021·Current Problems in Cardiology·Ahmed Al-AdhamiNawwar Al-Attar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.