Abstract
Even organs from an ideal donor will occasionally develop primary graft dysfunction (PGD) causing a significant morbidity and mortality after transplantation. It is likely that this situation represents subtle undetectable levels of ongoing donor organ dysfunction. The aim of this study is to investigate the association of PGD between lung, kidney and heart recipients from the one donor. From 202 multiorgan donors, contributed 231 consecutive lung transplants at the Alfred Hospital, 378 kidney and 114 heart transplants were subsequently performed at multiple centers across Australia and New Zealand. Eight hundred seventy-five organs were used for 723 transplants. The incidence of PGD after lung, kidney and heart transplants was 20% (47/231), 24% (92/378) and 20% (23/114), respectively. In paired single organ recipients, PGD in one of the pair was a significant risk factor for the development of PGD in the other [lung: odds ratio = 5.63 (1.72-18.43), p = 0.004; kidney: odds ratio = 3.19 (1.90-5.35), p < 0.0001]. In multivariate analysis, same donor heart PGD [3.37 (1.19-9.50), p = 0.02] was an independent risk factor for lung PGD and same donor lung PGD was significant risk factor for kidney PGD [1.94 (1.01-3.73), p = 0.04], if ...Continue Reading
References
Dec 1, 1992·The Annals of Thoracic Surgery·D A HaydockJ D Cooper
Feb 1, 1987·Transplantation·B A LucasF Sanfilippo
Sep 1, 1996·The Annals of Thoracic Surgery·K E SommersR J Keenan
Dec 15, 1996·Transplantation·F G CosioR M Ferguson
Feb 11, 1998·Transplantation·W W PfaffA I Reed
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·R OberbauerG Mayer
Nov 15, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G I SnellT J Williams
Dec 16, 2000·Transplantation·E J BirksN Latif
Jun 8, 2001·Transplantation·E V PotapovR Hetzer
Aug 15, 2001·Transplantation·P SchnuelleF J van der Woude
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S L NybergM D Stegall
Nov 27, 2002·Transplantation·Friedrich K PortPhilip J Held
Feb 14, 2003·Current Opinion in Urology·Christoph Schwarz, Rainer Oberbauer
Oct 14, 2003·Chest·Jason D ChristieStephen E Kimmel
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·William D IrishMark A Schnitzler
Jan 2, 2004·Transplantation·Jacqueline M A SmitsUNKNOWN Eurotransplant Study on Twin Lung Transplants (ESOTWIN) Study Group
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc de PerrotUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Nov 1, 2005·The Journal of Thoracic and Cardiovascular Surgery·Takahiro OtoGregory I Snell
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Silvana F MarascoMeroula Richardson
Jan 27, 2006·Transplantation·Jonathan A GrossbergPaul E Morrissey
Jul 6, 2006·Circulation·Brian LimaCarmelo A Milano
Dec 5, 2006·The Journal of Thoracic and Cardiovascular Surgery·Takahiro OtoGregory I Snell
Dec 23, 2006·The Annals of Thoracic Surgery·Takahiro OtoGregory I Snell
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V S AvlonitisJ H Dark
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S McDonaldS Chadban
Apr 7, 2007·Transplantation·Paul E Morrissey
Apr 24, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Takahiro OtoGregory I Snell
Nov 29, 2007·Annals of Surgery·Mark-Hugo J MaathuisThomas Minor
Mar 25, 2008·International Journal of Surgery·David K C Cooper
Citations
Aug 27, 1990·Biochimica Et Biophysica Acta·P F Miller, A G Hinnebusch
Jan 4, 2012·British Journal of Anaesthesia·D W McKeownJ A Kellum
Mar 17, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Aldo CannataLuigi Martinelli
Aug 13, 2011·Journal of Transplantation·Arjun IyerPeter Simon Macdonald
Apr 23, 2009·American Journal of Respiratory and Critical Care Medicine·Vibha N Lama
Oct 14, 2014·The American Journal of the Medical Sciences·Andres PelaezDavid M Guidot
Apr 23, 2011·Clinics in Chest Medicine·Gregory I Snell, Glen P Westall
May 25, 2010·The Annals of Thoracic Surgery·Tomokazu KakishitaShinichiro Miyoshi
May 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Seyedhossein AharinejadMichael Grimm
Dec 14, 2011·Clinical Transplantation·Silvana F MarascoTrevor Williams
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SalamaS Aharinejad
Mar 26, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference participants
Jul 24, 2010·Journal of the American College of Cardiology·Vamsidhar B DronavalliRobert S Bonser
Jun 9, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Lakshmi Kumar
Jan 29, 2016·PloS One·David M de KretserRobyn E O'Hehir
Mar 21, 2017·Medicina intensiva·C Chamorro-JambrinaM S Pérez-Cornejo
Mar 20, 2018·Current Opinion in Organ Transplantation·Eugene C DePasquale, Abbas Ardehali
Sep 30, 2016·World Journal of Transplantation·Raffaele Girlanda
Jul 22, 2009·Current Opinion in Organ Transplantation·Gregory I Snell, Glen P Westall
Mar 15, 2019·Clinical Transplantation·Samuel JacobSi M Pham
Apr 26, 2019·Heart Failure Reviews·Sanjeet Singh Avtaar SinghNawwar Al-Attar
Dec 14, 2019·Clinical Transplantation·Tsuyoshi TakahashiRamsey R Hachem
Dec 9, 2020·The Journal of Clinical Investigation·Daniel R CalabreseJohn R Greenland
Oct 9, 2015·Physiological Research·O SzarszoiI Netuka
Jan 9, 2018·Biomaterials·Charles A ChangRobert R Kane
Sep 24, 2009·Circulation·Seyedhossein AharinejadMichael Grimm
Aug 19, 2021·Current Problems in Cardiology·Ahmed Al-AdhamiNawwar Al-Attar