Association Between Prior Calcium Channel Blocker Use and Mortality in Septic Patients: A Meta-Analysis of Cohort Studies.

Frontiers in Pharmacology
Xianfei DingTongwen Sun

Abstract

Background: The aim of this study was to comprehensively review the literature and synthesize the evidence concerning the relationship between prior calcium channel blocker (CCB) use and mortality in patients with sepsis. Methods: The Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Cochrane CENTRAL, and Web of Science databases were searched from their inception to April 9, 2020. Cohort studies related to prior calcium channel blocker use in patients with sepsis were analyzed. Pairs of reviewers independently screened the studies, extracted the data, and assessed the risk of bias. The primary outcome of 90-days mortality or secondary outcome of short-term mortality, including 30-days, Intensive Care Unit (ICU), and in-hospital mortality, were analyzed. Heterogeneity among studies was assessed using the I2 statistic and was considered moderate if I2 was 50-75% and high if I2 was ≥75%. Random-effects models were used to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs). The quality of the studies was evaluated with the Newcastle-Ottawa Scale (NOS). Sensitivity analyses were performed to examine the robustness of the results. Results: In total, 639 poten...Continue Reading

References

Aug 1, 1993·The American Journal of Physiology·D R MeldrumI H Chaudry
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S K SongR S Hotchkiss
Aug 26, 1998·Biochemical Pharmacology·R P MasonP E Mason
Aug 13, 1999·The American Journal of Physiology·S B Mustafa, M S Olson
Oct 4, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·M HayashiT Saruta
Nov 18, 2000·The Journal of Physiology·M R Duchen
Aug 9, 2001·Statistical Methods in Medical Research·J B Copas, J Q Shi
Mar 11, 2003·Critical Care Medicine·R Phillip Dellinger
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 5, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G LiJ S Li
Sep 16, 2006·BMJ : British Medical Journal·Joseph LauIngram Olkin
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wei-Jian ZhangBalz Frei
Nov 28, 2007·Annual Review of Pathology·Zheng DongManjeri A Venkatachalam
Dec 18, 2007·Cell·David E Clapham
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Feb 28, 2013·Critical Care Medicine·David F GaieskiBrendan G Carr
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Nov 16, 2013·Nature Reviews. Immunology·Richard S HotchkissDidier Payen
Jan 26, 2016·American Journal of Respiratory and Critical Care Medicine·Shuo-Ming OuYung-Tai Chen
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jan 13, 2017·Critical Care Medicine·Maryse A WiewelUNKNOWN Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium
Jan 19, 2017·Critical Care Medicine·Andrew RhodesR Phillip Dellinger
Jan 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke SuetaSeiji Hokimoto
Sep 6, 2019·Critical Care : the Official Journal of the Critical Care Forum·Kaiquan TanMarek Nalos

❮ Previous
Next ❯

Software Mentioned

Emtree
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.