Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy

Tissue Antigens
P SaccucciN Bottini

Abstract

The missense PTPN22 C1858T polymorphism recently emerged as an important population-independent risk factor for type 1 diabetes (T1D) and other autoimmune diseases. The PTPN22 gene encodes the lymphoid tyrosine phosphatase (LYP), a negative regulator of signal transduction through the T-cell receptor. Although the frequency of the polymorphism is variable among different ethnic groups, the association between PTPN22 *T1858 and T1D has been replicated in several populations. Here, we contribute the first replication of the association between PTPN22 and T1D in populations from continental Italy, carried out in two independent samples of T1D patients (N = 216 and 82) and controls (N = 271 and 89). Our data also suggest that T1D carriers of the *T1858 allele could be at increased risk for other comorbid autoimmune disorders.

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Citations

Dec 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Georg DultzGeorge J Kahaly
Sep 22, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria Luisa Manca BittiFulvia Gloria-Bottini
May 19, 2010·Biomarkers in Medicine·Neeraj KumarNarinder Mehra
Aug 13, 2013·BioMed Research International·Styliani GizaAssimina Galli-Tsinopoulou
May 7, 2010·Genes and Immunity·M MaziarzUNKNOWN Diabetes Incidence in Sweden Study Group
Mar 6, 2010·Seminars in Immunopathology·Stephanie M StanfordNunzio Bottini
May 20, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·M L Manca BittiF Gloria-Bottini
Dec 27, 2011·Neuromuscular Disorders : NMD·Carlo ProvenzanoEmanuela Bartoccioni
Dec 30, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Fulvia Gloria-BottiniEgidio Bottini
Feb 7, 2018·The Journal of Clinical Endocrinology and Metabolism·Juliane HouckenGeorge J Kahaly
Jul 10, 2018·Current Diabetes Reviews·Wafaa Moustafa M Abo El FotohAbeer Hamdy El Shalakany
Nov 30, 2010·Molecular Biology Reports·Valerio NapolioniNazzareno Lucarini

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