Association between radiographic hand osteoarthritis and RANKL, OPG and inflammatory markers

Osteoarthritis and Cartilage
I PantsulaiaE Kobyliansky

Abstract

The aim of the study was to evaluate the association between prevalence and severity of radiographic hand osteoarthritis (OA) and serum levels of systemic inflammatory markers in a community-based population sample. A cross-sectional observational study was conducted on a population comprised 1452 Chuvashians (763 males, aged 49.23 ± 17.43; and 689 females, aged 50.37 ± 17.47 years). OA was evaluated in 14 joints of each hand using Kellgren and Lawrence (K-L), joint space narrowing (JSN) and osteophyte (OS) scores. Serum levels of systemic inflammatory and osteoclastogenic cytokines were measured by an enzyme-linked immunosorbent assay (ELISA). Statistical analyses included descriptive statistics, correlation analysis and multiple linear regressions. Monocyte chemotactic protein-1 (MCP-1) and osteoprotegerin (OPG) levels were associated with OA traits, but the statistically significant correlations were weak and/or moderate. In particular, the MCP-1 inflammation marker showed a statistically significant association with JSN (β=0.077, P=0.022) and OS (β=0.067, P=0.024) scores, but not with the number of affected joints (K-L ≥ 2). OPG was significantly correlated with the scores as to the number of affected joints (β=0.063, P=0.0...Continue Reading

References

Jun 3, 2004·Journal of Medical Genetics·G LivshitsE Kobyliansky
Aug 5, 2004·Rheumatology·C S Bonnet, D A Walsh
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Peter S BurrageConstance E Brinckerhoff
Jul 29, 2006·Arthritis and Rheumatism·S DahaghinB W Koes
Feb 27, 2007·Osteoarthritis and Cartilage·R D Altman, G E Gold
Jun 26, 2007·Biogerontology·Ida MalkinEugene Kobyliansky
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Johanne Martel-PelletierPeter J Roughley
Dec 17, 2008·Annals of the Rheumatic Diseases·M B GoldringY Li
Feb 3, 2009·Rheumatology International·Antoaneta TonchevaNina Ivanovska
Apr 29, 2009·The Keio Journal of Medicine·Steeve Kwan TatJohanne Martel-Pelletier
Jun 13, 2009·Arthritis Research & Therapy·Mary B Goldring, Kenneth B Marcu
Sep 19, 2009·Rheumatology·Steeve Kwan TatJohanne Martel-Pelletier

❮ Previous
Next ❯

Citations

Jun 1, 2013·Annals of the Rheumatic Diseases·Devi Rani SagarVictoria Chapman
Sep 4, 2015·Biomolecules & Therapeutics·Jin Sung ParkSun-Chul Hwang
Mar 28, 2012·Clinical Biochemistry·Minghui Liu, Chunhe Hu
Feb 6, 2015·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Feng GaoMeng Yao
Oct 4, 2011·Biochemical Pharmacology·Santos CastañedaGabriel Herrero-Beaumont
Mar 22, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yun ZhouGuohui Yang
May 9, 2015·Osteoarthritis and Cartilage·M KloppenburgUNKNOWN OARSI Hand Clinical Trial Recommendations Work Group
Mar 5, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dae Cheol NamSun-Chul Hwang
Nov 4, 2017·Rheumatology International·Tereza LennerováLadislav Šenolt
Sep 29, 2019·Journal of Clinical Medicine·Anna BenderJuergen Steinmeyer
Jan 10, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ho Jong RaSun-Chul Hwang
Mar 11, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dong-Geun KangJin Sung Park
Apr 16, 2019·Mediators of Inflammation·Antonella FioravantiDavid S Gibson
Nov 11, 2020·Journal of Orthopaedic Surgery and Research·Feifei NiJianjun Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.