Abstract
The present study aimed to investigate whether single nucleotide polymorphisms in receptor interacting serine/threonine kinase 2 (RIPK2), which encodes a component of the nucleotide binding oligomerization domain containing 2-RIP2 pathway, may compromise the innate immune response toHelicobacter pyloriinfection, leading to increased susceptibility to gastric cancer in the Japanese population. The present case control study investigated the associations betweenRIPK2single nucleotide polymorphisms and gastric mucosal inflammation, atrophy and cancer susceptibility in 528 patients with gastric cancer and 697 patients without gastric malignancies on upper gastro-duodenal endoscopy. Overall, theRIPK2rs16900627 minor allele was significantly associated with the susceptibility to gastric cancer [OR, 1.37; 95% confidence interval (CI), 1.06-1.77; P=0.016], particularly of the intestinal type (OR, 1.53; 95% CI, 1.13-2.07; P=0.0062). It was also significantly associated with gastric mucosal atrophy (OR, 1.83; 95% CI, 1.14-2.93; P=0.011). When assessing the severity of chronic gastritis using the updated Sydney system, the activity and inflammation scores, as well as atrophy and metaplasia scores, were significantly higher in rs16900627 m...Continue Reading
References
Jul 1, 1994·The Journal of Clinical Investigation·M J Blaser, J Parsonnet
Apr 1, 1996·Alimentary Pharmacology & Therapeutics·J E Crabtree
Oct 1, 1996·The American Journal of Surgical Pathology·M F DixonP Correa
Jun 3, 1998·Gastroenterology·J Q HuangR H Hunt
Nov 23, 2000·The Journal of Biological Chemistry·Y OguraG Nunez
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Feb 19, 2002·Alimentary Pharmacology & Therapeutics·M F Go
Jan 1, 1965·Acta Pathologica Et Microbiologica Scandinavica·P LAUREN
Jul 6, 2006·Cellular Microbiology·Philip RosenstielStefan Schreiber
Oct 17, 2006·Clinical Microbiology Reviews·Holly M Scott Algood, Timothy L Cover
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Kazuko NakashimaMayumi Tamari
Aug 23, 2007·Cancer Science·Tomomitsu TaharaHiroshi Nakano
Mar 11, 2009·Gastroenterology·Roland RadAnne Krug
Mar 17, 2010·Experimental and Molecular Pathology·Andrzej HnatyszynRyszard Slomski
Apr 15, 2010·The Journal of Clinical Investigation·Tomohiro WatanabeWarren Strober
Nov 15, 2011·Mutagenesis·Jing LiDong-Qing Ye
Apr 24, 2012·Biochimica Et Biophysica Acta·Justine T Tigno-Aranjuez, Derek W Abbott
May 23, 2012·International Journal of Oncology·Tomiyasu ArisawaTomoyuki Shibata
Apr 9, 2013·PloS One·Natalia Castaño-RodríguezHazel M Mitchell
Jul 3, 2013·European Journal of Immunology·Dong-Jae KimGabriel Núñez
Sep 10, 2013·PloS One·Patrick MarcinekThirumalaisamy P Velavan
Mar 4, 2014·PloS One·Jingwei LiuYuan Yuan
Oct 23, 2014·Journal of Cancer Prevention·Ju Yup LeeDong Ho Lee
May 2, 2015·PloS One·Zhe-Xuan LiKai-Feng Pan
Nov 12, 2015·PloS One·Ya-Kai HuangChao Yan
Citations
Aug 11, 2020·Journal of Immunology Research·Siru Nie, Yuan Yuan
Feb 27, 2021·Frontiers in Genetics·Qian YangWeiguo Dong
May 1, 2021·Scientific Reports·Hui-Yi LinJong Y Park
Aug 28, 2021·Biomedicines·Supattra ChaithongyotMichael Naumann