Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility

Oncology Letters
Masafumi OtaTomiyasu Arisawa

Abstract

The present study aimed to investigate whether single nucleotide polymorphisms in receptor interacting serine/threonine kinase 2 (RIPK2), which encodes a component of the nucleotide binding oligomerization domain containing 2-RIP2 pathway, may compromise the innate immune response toHelicobacter pyloriinfection, leading to increased susceptibility to gastric cancer in the Japanese population. The present case control study investigated the associations betweenRIPK2single nucleotide polymorphisms and gastric mucosal inflammation, atrophy and cancer susceptibility in 528 patients with gastric cancer and 697 patients without gastric malignancies on upper gastro-duodenal endoscopy. Overall, theRIPK2rs16900627 minor allele was significantly associated with the susceptibility to gastric cancer [OR, 1.37; 95% confidence interval (CI), 1.06-1.77; P=0.016], particularly of the intestinal type (OR, 1.53; 95% CI, 1.13-2.07; P=0.0062). It was also significantly associated with gastric mucosal atrophy (OR, 1.83; 95% CI, 1.14-2.93; P=0.011). When assessing the severity of chronic gastritis using the updated Sydney system, the activity and inflammation scores, as well as atrophy and metaplasia scores, were significantly higher in rs16900627 m...Continue Reading

References

Jul 1, 1994·The Journal of Clinical Investigation·M J Blaser, J Parsonnet
Apr 1, 1996·Alimentary Pharmacology & Therapeutics·J E Crabtree
Nov 23, 2000·The Journal of Biological Chemistry·Y OguraG Nunez
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Feb 19, 2002·Alimentary Pharmacology & Therapeutics·M F Go
Oct 17, 2006·Clinical Microbiology Reviews·Holly M Scott Algood, Timothy L Cover
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Kazuko NakashimaMayumi Tamari
Apr 24, 2012·Biochimica Et Biophysica Acta·Justine T Tigno-Aranjuez, Derek W Abbott
May 23, 2012·International Journal of Oncology·Tomiyasu ArisawaTomoyuki Shibata
Mar 4, 2014·PloS One·Jingwei LiuYuan Yuan

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Citations

Aug 11, 2020·Journal of Immunology Research·Siru Nie, Yuan Yuan
May 1, 2021·Scientific Reports·Hui-Yi LinJong Y Park
Aug 28, 2021·Biomedicines·Supattra ChaithongyotMichael Naumann

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