Abstract
Red blood cell distribution width (RDW) is a strong prognostic marker for various medical conditions, such as ischemic strokes. However, the relationships between higher RDW and the subtypes of white matter hyperintensities (WMHs) remain unclear. Hence, this study aimed to thoroughly evaluate the relationships between RDW and the subtypes of WMHs. This cross-sectional study was a retrospective analysis of hospital database (Dongguan Medical System, from April 2015 to February 2017). The presence and subtypes of WMHs were evaluated using Fazekas score with the T2WI-FLAIR brain images from a 1.5-T MRI system. The overall sample was randomly split in half. One of the two split-half samples was used for determining the optimal cutoff value of higher RDW and another for further statistical analyses. A total of 555 subjects with WMHs and 642 controls were recruited. The optimal cutoff value of higher RDW was 13.25%. Logistic regression revealed that higher RDW (≥13.25%) was positively associated with periventricular WMHs (adjusted OR = 1.81, 95% CI: 1.16-2.82, p = .009). However, higher RDW was not associated with total WMHs (adjusted OR = 1.52, 95% CI: 0.99-2.33, p = .057) and deep WMHs (adjusted OR = 1.21, 95% CI: 0.76-1.94, p = .4...Continue Reading
References
Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Jan 1, 1987·Archives of Neurology·V C HachinskiH Merskey
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·L Pantoni, J H Garcia
Dec 4, 2004·Stroke; a Journal of Cerebral Circulation·Charles DeCarliWilliam J Jagust
Jun 28, 2006·Diabetes Care·Vera NovakLewis A Lipsitz
Apr 7, 2007·Neurosurgery·Rose DuMichael T Lawton
Apr 20, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Maria Cornelia StoeckelRüdiger J Seitz
May 3, 2008·Stroke; a Journal of Cerebral Circulation·Daniel M MandellDavid J Mikulis
Aug 22, 2009·Stroke; a Journal of Cerebral Circulation·Clinton B WrightMitchell S V Elkind
Dec 23, 2009·European Journal of Heart Failure·Roland R J van KimmenadeJames L Januzzi
Oct 28, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nerses SanossianDavid S Liebeskind
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Chris MoranVelandai K Srikanth
Dec 24, 2011·Gut and Liver·Atakan YeşilAyşe Oya Kurdaş Övünç
Jun 29, 2012·Thrombosis and Haemostasis·Jinkwon KimJi Hoe Heo
Jul 31, 2012·Neurology·Catherine C PriceDavid J Libon
Aug 11, 2012·Advances in Experimental Medicine and Biology·Kushang V PatelJoseph M Rifkind
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
Jun 12, 2013·Alzheimer Disease and Associated Disorders·Jennifer WeuveDenis A Evans
Nov 1, 2013·Thrombosis and Haemostasis·Yaron ArbelVarda Shalev
Jan 30, 2015·Neurology·Melinda C PowerRebecca F Gottesman
Feb 20, 2015·American Journal of Epidemiology·Paul D Loprinzi, Earl S Ford
Nov 12, 2015·Stroke; a Journal of Cerebral Circulation·Johanna HeleniusNils Henninger
Feb 27, 2016·PloS One·Han-Bin LeeOk-Joon Kim
May 6, 2016·Oncotarget·Monika PodhoreckaZbigniew Darzynkiewicz
May 22, 2016·Diabetes Care·Mark A EspelandUNKNOWN Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group
Jun 4, 2016·Translational Stroke Research·Genlong ZhongMin Lou
Feb 25, 2017·Scientific Reports·Haifeng HouDong Li
Apr 8, 2017·Oncotarget·Shujuan ZhouSongfu Jiang