Association between red blood cell transfusion and long-term mortality in patients with cancer of the esophagus after esophagectomy

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
Joohyun LeeIn-Cheol Choi

Abstract

The impact of red blood cell transfusion on long-term mortality has not been well characterized in patients with cancer of the esophagus after esophagectomy. Our retrospective observational study investigated 611 patients with cancer of the esophagus after esophagectomy from January 2005 to December 2012. Perioperative red blood cell transfusion was defined as red blood cell transfusion during intraoperative and postoperative period. One hundred ninety-six (32.1%) patients received red blood cell transfusion. During follow-up period, 153 (36.9%) patients without red blood cell transfusion and 120 (61.2%) patients with red blood cell transfusion died. Multivariable analysis identified that there was an incremental association between the amount of red blood cell transfusion and long-term mortality (hazard ratio 1.06, 95% confidence interval 1.04-1.08, P < 0.001). The association between red blood cell transfusion and worse long-term mortality was also demonstrated in propensity-matched patients (hazard ratio 1.62, 95% confidence interval 1.15-2.28, P = 0.006). Therefore, there might be an independent association between perioperative red blood cell transfusion and worse long-term mortality in patients with cancer of the esophagu...Continue Reading

References

Oct 12, 1978·The New England Journal of Medicine·G Opelz, P I Terasaki
Aug 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·S G SwisherD W McFadden
Sep 2, 1998·The Annals of Thoracic Surgery·S R CraigW S Walker
Mar 23, 1999·The American Journal of Gastroenterology·M TachibanaN Nagasue
Oct 4, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S M DresnerS M Griffin
Feb 7, 2002·Annals of Surgical Oncology·Woo Jin HyungJin Sik Min
Jun 25, 2002·The Annals of Thoracic Surgery·Stephen M LangleyDavid F Weeden
Sep 19, 2002·American Journal of Therapeutics·Morris A Blajchman
Sep 7, 2007·Blood Reviews·Eleftherios C Vamvakas, Morris A Blajchman
Nov 27, 2008·Anesthesiology·Shir AtzilShamgar Ben-Eliyahu
Feb 14, 2012·The Journal of Thoracic and Cardiovascular Surgery·Thomas NgWilliam G Cioffi

❮ Previous
Next ❯

Citations

Jun 20, 2020·Blood·Jeffrey A Gilreath, George M Rodgers
Nov 8, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Anitha KammiliCarmen Leandra Mueller
Jun 17, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Samuel Torres-LandaStephanie G Wood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.