Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies

Blood
Jorge CastilloSheila K Pascual

Abstract

The incidence of non-Hodgkin lymphoma (NHL) has increased steadily for the past few decades. Previous studies have suggested an association between blood transfusions and NHL. The main objective of this study was to evaluate this relationship with a meta-analysis of observational studies. A literature search was undertaken, looking for case-control and cohort studies evaluating the risk of developing NHL in persons who received allogeneic blood transfusions; 14 studies were included. Outcome was calculated and reported as relative risk (RR). Heterogeneity was assessed with Cochrane Q and I(2) statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis. Quality assessment was performed with the Newcastle-Ottawa scale. Our analysis showed a RR of developing NHL of 1.05 (95% CI, 0.89-1.25; P = .42) and 1.34 (95% CI, 1.15-1.55; P < .01) in case-control and cohort studies, respectively. When pooling all studies, RR was 1.2 (95% CI, 1.07-1.35; P < .01). In subset analysis, RR of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 1.66 (95% CI, 1.08-2.56; P = .02). The RR of NHL was elevated in both men and women and in persons receiving transfusions either before or after 199...Continue Reading

References

Oct 24, 1991·The New England Journal of Medicine·E van TwuyverL P de Waal
Jan 1, 1995·Immunological Investigations·M A Blajchman, J O Bordin
Aug 1, 1994·International Journal of Cancer. Journal International Du Cancer·A Memon, R Doll
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J BlombergM Jonsson
May 1, 1996·British Journal of Cancer·L BrandtT Möller
Sep 1, 1997·Annals of Internal Medicine·J AdamiB Glimelius
Nov 25, 1998·Journal of the National Cancer Institute·R A NelsonL Bernstein
Jun 16, 1999·American Journal of Epidemiology·E K Maguire-BostonA R Folsom
Aug 5, 1999·Journal of the National Cancer Institute·A TavaniS Franceschi
Sep 3, 1999·Clinical and Diagnostic Laboratory Immunology·S A Kirkley
Aug 3, 2004·American Journal of Epidemiology·Yawei ZhangTongzhang Zheng
Oct 14, 2004·Annals of Hematology·Antonia M S MüllerMonika Engelhardt
Dec 24, 2005·Pathology·Andrew E Grulich, Claire M Vajdic
Oct 14, 2006·BMC Medical Research Methodology·Leon BaxKarel G M Moons
Dec 13, 2007·Journal of the National Cancer Institute·Henrik HjalgrimMads Melbye
May 29, 2008·International Journal of Cancer. Journal International Du Cancer·James R CerhanMartha Linet
Nov 27, 2008·Diabetes Care·Joanna MitriAnastassios G Pittas
Nov 27, 2008·Anesthesiology·Shir AtzilShamgar Ben-Eliyahu
Feb 24, 2009·Biologicals : Journal of the International Association of Biological Standardization·Roger DoddGirish Vyas
May 6, 2009·Transfusion·Joseph SweeneyJonathan Kurtis
May 16, 2009·International Journal of Cancer. Journal International Du Cancer·Eva ErberLaurence N Kolonel

❮ Previous
Next ❯

Citations

Jan 1, 2014·Nature Reviews. Drug Discovery·Andrew W BoydMartin Lackmann
Aug 29, 2013·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Hongliang ShenMing Qiu
May 18, 2012·British Journal of Anaesthesia·D R SpahnA Hofmann
Jun 21, 2014·Future Oncology·John L Reagan, Jorge J Castillo
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Axel HofmannAryeh Shander
Nov 3, 2012·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Spyridon N PapageorgiouMoschos A Papadopoulos
Oct 13, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ning LiMin-Qiang Lu
Apr 15, 2016·Cancer Causes & Control : CCC·Angelo G SoliminiMaria De Giusti
Oct 9, 2014·BioMed Research International·Christina KalpadakisMaria K Angelopoulou
Jan 27, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ryo SeishimaYuko Kitagawa
Mar 1, 2014·Blood·Maryalice Stetler-Stevenson
Jul 28, 2011·Anesthesiology·Brian M GillissMichael A Gropper
Sep 30, 2016·Cancer Epidemiology·Maria C DiumenjoMonica S Sierra
Sep 12, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Bernhard ZieglerCristina Solomon
Jun 27, 2012·The American Journal of Gastroenterology·Koji OkabayashiThanos Athanasiou
Oct 23, 2010·Blood·James R Cerhan
Oct 5, 2011·The Oncologist·Dirk Schrijvers
Jun 18, 2019·Therapeutic Advances in Medical Oncology·Elena Gabriela ChioreanSalah-Eddin Al-Batran
Sep 17, 2020·Einstein·Carlos João Schaffhausser FilhoRoseli Oselka Saccardo Sarni
Jun 6, 2019·Cancer Causes & Control : CCC·James R CerhanPaige M Bracci

Jul 29, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Apr 12, 2018·Revista da Associação Médica Brasileira·João Carlos Pina FariaRoseli Oselka Saccardo Sarni
Feb 15, 2014·Expert Review of Hematology·Jeannette S von Lindern, Enrico Lopriore
Dec 7, 2011·Cancer Control : Journal of the Moffitt Cancer Center·Yvonne M Mowery, Mark C Lanasa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Eric A Engels
International Journal of Cancer. Journal International Du Cancer
Dominik D AlexanderDimitrios Trichopoulos
© 2021 Meta ULC. All rights reserved