Abstract
The association between circulating biomarkers of red blood cells (RBC) omega-3 polyunsaturated fatty acids (PUFAs) and cerebral white matter hyperintensities (WMH) on the brain MRI remains yet unclear. We investigated the cross-sectional and prospective associations of RBC omega-3 PUFAs with WMH in dementia-free older adults with subjective memory complaints. Participants were 234 older adults with assessments for both PUFA and MRI near to baseline; among them, 79 also had an MRI assessment at 3-year follow-up. The measurement of WMH volume was obtained by an automated segmentation algorithm. We related individual or combinational baseline RBC omega-3 PUFAs levels with baseline WMH volumes and WMH evolution over 3 years. We carried out multiple (cross-sectional) and mixed-effect (prospective analysis, with random effects at participant's level) linear regressions with adjustment for age, sex, time interval between date of blood draw for measurement of fatty acids and date of brain MRI, the status of APOE e4 carrier, body mass index, and vascular risk factors. Associations were considered significant at p ≤ 0.006 to take into account multiplicity (8 comparisons). None of the eight RBC omega-3 PUFAs tested was significantly asso...Continue Reading
References
Sep 9, 2004·Circulation·William S HarrisA Michael Borkon
Nov 15, 2006·Archives of Neurology·Ernst J SchaeferPhilip A Wolf
Oct 9, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Antonio CherubiniLuigi Ferrucci
Apr 25, 2009·Stroke; a Journal of Cerebral Circulation·Carole DufouilUNKNOWN PROGRESS MRI Substudy Investigators
Jul 8, 2009·BMJ : British Medical Journal·Domenico InzitariUNKNOWN LADIS Study Group
Sep 8, 2009·Clinical Biochemistry·William S Harris, Rachael M Thomas
Dec 17, 2009·Lipids·Philippe LegrandP Weill
Dec 30, 2011·Neurology·G L BowmanJ F Quinn
Mar 1, 2012·Neurology·Z S TanS Seshadri
Jun 8, 2012·Human Brain Mapping·Michelle W VossArthur F Kramer
Nov 16, 2012·PloS One·Thomas SamailleMarie Chupin
Oct 12, 2013·Journal of the American Heart Association·Jyrki K VirtanenDariush Mozaffarian
Jan 1, 2014·Frontiers in Aging Neuroscience·Gene L BowmanJoseph F Quinn
Apr 30, 2015·Nutrition Research·Tae-Jin SongYong-Jae Kim
Nov 20, 2015·BioMed Research International·Michihiro SuwaMasaya Kino
Dec 17, 2015·Geriatrics & Gerontology International·Kumiko NagaiKoichi Kozaki
Jun 9, 2016·The Journal of Nutrition, Health & Aging·D SibbrittJ Adams
Dec 22, 2016·The Journal of Nutrition, Health & Aging·E L BostockG L Onambélé
Dec 22, 2016·The Journal of Nutrition, Health & Aging·E L BostockG L Onambélé
Jan 24, 2017·The Journal of Nutrition, Health & Aging·Y Y ZhangH M Tian
Apr 1, 2017·Lancet Neurology·Sandrine AndrieuUNKNOWN MAPT Study Group
Apr 28, 2017·The Journal of Nutrition, Health & Aging·G IolasconF Gimigliano
Citations
Jul 4, 2020·Scientific Reports·Dhavamani SugasiniPapasani V Subbaiah
Feb 20, 2021·Ageing Research Reviews·Tony MacaronPhilipe de Souto Barreto
Nov 5, 2021·Neurology·Aline ThomasCecilia Samieri