Association between renal dysfunction and 3-year mortality in patients with acute first-ever ischemic stroke

Clinical Neurology and Neurosurgery
Shun-Wen LinWen-Yi Huang

Abstract

The influence of renal dysfunction on the clinical presentation and outcomes of patients with acute ischemic stroke is still controversial. We investigate the influence of renal dysfunction on the outcomes of patients with acute first-ever ischemic stroke. Nine-hundred thirty-four patients with acute first-ever ischemic stroke were enrolled and followed for 3 years. Renal function was assessed using the equation of the Modification Diet for Renal Disease for estimated glomerular filtration rate (eGFR). Serum creatinine levels were obtained within 3 days of acute stroke onset. Reduced eGFR was defined as eGFR<60ml/min/1.73m(2). Clinical presentation, risk factors for stroke, laboratory data, co-morbidities, and outcomes were recorded. Total 264 patients (28.3%) had a reduced eGFR. The prevalence of older age, hypertension, and atrial fibrillation was significantly higher in patients with a reduced eGFR. Total anterior circulation syndrome occurred more frequently among patients with a reduced eGFR (P=0.010). Multivariate Cox regression revealed that a reduced eGFR is a significant predictor of 3-year mortality (HR=1.67, 95% CI=1.06-2.62, P=0.026). Reduced eGFR during the acute stroke stage is associated with increased risk of 3-...Continue Reading

References

Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·H H HuB N Chiang
Feb 1, 1991·Journal of Internal Medicine·P J Friedman
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·J C Gautier
Feb 5, 2000·Acta Neurologica Scandinavica·A ArboixC Targa
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·Graeme J HankeyE G Stewart-Wynne
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Dawn M BravataThomas P Meehan
Mar 15, 2003·Stroke; a Journal of Cerebral Circulation·Ruediger HilkerWolf-Dieter Heiss
Jul 5, 2003·Stroke; a Journal of Cerebral Circulation·Kate HardieCraig S Anderson
Sep 13, 2003·Kidney International·Haimanot WasseCatherine O Stehman-Breen
Oct 9, 2003·Kidney International. Supplement·Robert D Toto
Jan 30, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Agata WłodekAnna Członkowska
Feb 8, 2006·Annals of Internal Medicine·Mahboob RahmanALLHAT Collaborative Research Group
Dec 23, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hsin-Wei KuoChun-Yuh Yang
Mar 9, 2007·Journal of the American Society of Nephrology : JASN·Anna KottgenJosef Coresh
Sep 22, 2007·Stroke; a Journal of Cerebral Circulation·Terence J QuinnKennedy R Lees
Sep 29, 2007·Stroke; a Journal of Cerebral Circulation·Hakan AyA Gregory Sorensen
Oct 19, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T Hojs FabjanB Pecovnik Balon
Apr 25, 2008·Critical Care Medicine·Fidel BarrantesConstantine A Manthous
Sep 26, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Kerstin Amann
Dec 9, 2008·Lancet·Pierre DelanayeJean-Marie Krzesinski
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Feb 27, 2009·Journal of Rehabilitation Medicine·Der-Sheng HanTyng-Guey Wang
Jul 23, 2009·European Neurology·Huan-Lin HsuJiann-Der Lee
Aug 15, 2009·Stroke; a Journal of Cerebral Circulation·Terence J QuinnKennedy R Lees
Jan 29, 2010·Clinical Neurology and Neurosurgery·Ku-Chou ChangYu-Ching Huang
Feb 20, 2010·Stroke; a Journal of Cerebral Circulation·Sharon N PoissonS Andrew Josephson
May 21, 2010·American Journal of Nephrology·Helmy M Siragy, Robert M Carey
Oct 5, 2010·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
Jan 29, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Diego ViasusJordi Carratalà
Jun 22, 2011·Nature Reviews. Nephrology·Elke Wühl, Franz Schaefer

Citations

Jun 28, 2019·Topics in Stroke Rehabilitation·Hiroki KuboShinichi Shimada

Related Concepts

Atrial Fibrillation
Complication
Hypertensive Disease
Kidney Diseases
Laboratory
Patient Discharge
Regression Analysis
Cerebrovascular Accident
Dietary Modification
Creatinine Measurement, Serum (Procedure)

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.