Abstract
Renin-angiotensin-aldosterone system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident hospitalization and death from coronavirus disease 2019 (COVID-19). We investigated the association between use of angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARBs) or mineralocorticoid receptor antagonists (MRAs) and COVID-19 hospitalization/death in a large nationwide population. Patients with hypertension, heart failure, diabetes, kidney disease, or ischaemic heart disease registered in the Swedish National Patient Registry until 1 February 2020 were included and followed until 31 May 2020. COVID-19 cases were defined based on hospitalization/death for COVID-19. Multivariable logistic and Cox regressions were fitted to investigate the association between ACEi/ARB and MRA and risk of hospitalization/death for COVID-19 in the overall population, and of all-cause mortality in COVID-19 cases. We performed consistency analysis to quantify the impact of potential unmeasured confounding. Of 1 387 746 patients (60% receiving ACEi/ARB and 5.8% MRA), 7146 (0.51%) had incident hospitalization/death from COVID-19. After adjustment for 45 variable...Continue Reading
References
Sep 24, 2005·Circulation Research·Shlomo KeidarZaid Abassi
Jan 18, 2007·JAMA : the Journal of the American Medical Association·Ralph B D'Agostino, Ralph B D'Agostino
Nov 29, 2012·JAMA : the Journal of the American Medical Association·Lars H LundMagnus Edner
Nov 15, 2013·Journal of Virology·Adeline HeurichStefan Pöhlmann
Jan 16, 2016·European Journal of Epidemiology·Jonas F LudvigssonWeimin Ye
Aug 3, 2017·The New England Journal of Medicine·Thomas R Frieden
May 12, 2018·Journal of Inflammation Research·Mario MenkDavid Schwaiberger
Sep 16, 2019·International Journal of Cardiology·Gianluigi SavareseLars H Lund
Feb 20, 2020·The New England Journal of Medicine·Marc LipsitchLyn Finelli
Mar 14, 2020·Clinical Science·Daniel BatlleKarla Satchell
Apr 1, 2020·The New England Journal of Medicine·Muthiah VaduganathanScott D Solomon
Apr 18, 2020·Circulation Research·Venkatesh L MurthyRavi V Shah
Apr 18, 2020·Circulation Research·Peng ZhangHongliang Li
May 2, 2020·The New England Journal of Medicine·Giuseppe ManciaGiovanni Corrao
May 2, 2020·The New England Journal of Medicine·Harmony R ReynoldsJudith S Hochman
May 4, 2020·International Journal of Cardiology·Gianluigi SavareseLars H Lund
May 18, 2020·Lancet·Francisco J de AbajoUNKNOWN MED-ACE2-COVID19 study group
Jun 13, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Sophie LiabeufValérie Gras-Champel
Jun 20, 2020·JAMA : the Journal of the American Medical Association·Emil L FosbølLars Køber
Aug 2, 2020·Heart·Julia Hippisley-CoxPeter J Watkinson
Citations
Dec 23, 2020·Blood Pressure·Sverre E KjeldsenSuzanne Oparil
Jan 10, 2021·European Journal of Heart Failure·Daniela TomasoniMarco Metra
Dec 23, 2020·Journal of Occupational and Environmental Medicine·Marcos C BaptistaGlenn Pransky
Mar 12, 2021·Frontiers in Physiology·Simon B GressensEmmanuelle Vidal-Petiot
Apr 15, 2021·Clinics·Filipe FerrariRicardo Stein
May 1, 2021·International Journal of Molecular Sciences·Aneta AleksovaFederico Ferro
Apr 30, 2021·European Journal of Heart Failure·Matteo PagnesiMarco Metra
May 19, 2021·Journal of Neurology·Heather Angus-LeppanRoberto J Guiloff
Jul 3, 2021·Journal of Clinical Medicine·Emilia Roy-Vallejo On Behalf Of The Semi-Covid-Network
Jul 16, 2021·European Journal of Heart Failure·Gianluigi SavareseMarco Metra
Jul 30, 2021·Journal of the American Heart Association·Jordan LoaderJohan Sundström
Sep 12, 2021·Journal of Human Hypertension·Marijana Tadic, Cesare Cuspidi
Oct 30, 2021·Kardiologiia·E I TarlovskayaG P Arutyunov
Nov 7, 2021·GeroScience·Pasquale CampanaDario Leosco