Association between renin-angiotensin system inhibitors and COVID-19 complications.

European Heart Journal. Cardiovascular Pharmacotherapy
Sophie LiabeufValérie Gras-Champel

Abstract

To describe the characteristics of patients hospitalized with COVID-19 (including their long-term at-home medication use), and compare them with regard to the course of the disease. To assess the association between renin-angiotensin system inhibitors (RASIs) and disease progression and critical outcomes. All consecutive hospitalized patients with laboratory-confirmed COVID-19 in a university hospital in Amiens (France) were included in this study. The primary composite endpoint was admission to an intensive care unit (ICU) or death before ICU admission. Univariable and multivariable logistic regression models were used to identify factors associated with the composite endpoint. Between 28 February 2020 and 30 March 2020, a total of 499 local patients tested positive for SARS-CoV-2. Of these, 231 were not hospitalized {males 33%; median [interquartile range (IQR)] age: 44 (32-54)}, and 268 were hospitalized [males 58%; median (IQR) age: 73 (61-84)]. A total of 116 patients met the primary endpoint: 47 died before ICU admission, and 69 were admitted to the ICU. Patients meeting the primary endpoint were more likely than patients not meeting the primary endpoint to have coronary heart disease and to have been taking RASIs; howeve...Continue Reading

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Citations

Aug 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chia Siang Kow, Syed Shahzad Hasan
Sep 13, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Syed Shahzad HasanHamid A Merchant
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Clinical Trials Mentioned

NCT04351581

Software Mentioned

SAS
SPSS

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