Association between Repeated Praziquantel treatment and Papillary, and Intrahepatic Cholangiocarcinoma.

Annals of Hepatology
Vor LuviraVajarabhongsa Bhudhisawasdi

Abstract

The carcinogenesis of tubular and papillary cholangiocarcinoma (CCA) differ. The available epidemiologic studies about risk factors for CCA do not differentiate between the tubular and papillary type. The current study investigated the relationship between the number of repeated use of Praziquantel (PZQ) treatments and each type of CCA. This was a hospital-based, matched, case-control study of patients admitted to Srinagarind Hospital, Khon Kaen University. The patients were 210 pathologically-confirmed cases of CCA, while the controls were 840 subjects diagnosed with other diseases. The 4 controls were individually matched with each case by sex, age, and date of admission. The cases were classified according to location (intrahepatic vs. extrahepatic) and cell type (papillary vs. tubular). Multivariable conditional logistic regression was used for the analysis. After adjusting for confounders, there were statistically significant associations between intrahepatic and papillary CCA and repeated use of PZQ treatment. The respective odds of developing intrahepatic CCA for those who used PZQ once, twice, or more was 1.54 (95%CI:0.92-2.55 ), 2.28 (95%CI:0.91-5.73), and 4.21 (95%CI:1.61-11.05). The respective odds of developing papi...Continue Reading

Citations

Mar 5, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Alejandro FornerAngela Lamarca
Feb 1, 2021·Trends in Parasitology·Thomas CrellenT Déirdre Hollingsworth
Dec 5, 2020·International Journal of General Medicine·Attapol TitapunNarong Khuntikeo
Sep 14, 2021·The Cochrane Database of Systematic Reviews·Vor LuviraPorjai Pattanittum
Nov 6, 2021·Journal of Hepato-biliary-pancreatic Sciences·Vor LuviraAke Pugkhem

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