Association between respiratory impedance measured by forced oscillation technique and exacerbations in patients with COPD

International Journal of Chronic Obstructive Pulmonary Disease
Hitomi YamagamiHironori Sagara

Abstract

It is well known that increased airflow limitation as measured by spirometry is associated with the risk of exacerbation in patients with COPD. The forced oscillation technique (FOT) is a noninvasive method used to assess respiratory impedance (resistance and reactance) with minimal patient cooperation required. The clinical utility of the FOT in assessing the risk of exacerbations of COPD is yet to be determined. We examined the relationship between respiratory impedance as measured by FOT and exacerbations in patients with COPD. Among 310 patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stages I-IV) who presented at the outpatient clinic of the Showa University Hospital from September 2014 through January 2015, 119 were collected and assigned into 2 groups according to their history of exacerbation: exacerbators and nonexacerbators. Respiratory resistance components and respiratory reactance components, as measured by FOT, were compared between the two groups. Exacerbators were significantly older and had a higher white blood cell count than nonexacerbators. Resistance at 20 Hz, reactance at 5 Hz (X5), resonant frequency (Fres), and area of low reactance (ALX) differed significantly between the two g...Continue Reading

Citations

Jul 10, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Thibaut CapronPascal Chanez
Sep 4, 2020·Journal of Clinical Medicine·Tomoki UnoHironori Sagara
Feb 13, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Zhonghao TangHuili Zhu

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FOT
JMP
SAS

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