Association Between Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection in Early Life and Recurrent Wheeze and Asthma in Later Childhood.

The Journal of Infectious Diseases
Ting ShiRESCEU Investigators

Abstract

Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and subsequent respiratory sequelae up to age 12 years. We estimated the strength of association by 3 control groups and 3 follow-up age groups, with data from studies published between January 1995 and May 2018. We also estimated associations by diagnostic criteria, age at infection, and high-risk population. Overall, we included 41 studies. A statistically significant association was observed between early life RSV infection and subsequent childhood recurrent wheeze, in comparison to those who were healthy or those without respiratory symptoms: OR 3.05 (95% confidence interval [CI], 2.50-3.71) for 0 to <36 months follow-up age; OR 2.60 (95% CI, 1.67-4.04) for 36-72 months; and OR 2.14 (95% CI, 1.33-3.45) for 73-144 months. For the subsequent development of asthma, a statistically significant association was observed only in relation to those aged 73-144 months at follow-up: OR 2.95 (95% CI, 1.96-4.46). Further studies using standardized definitions and from diverse settings are needed to elucidate the role of confounders and...Continue Reading

References

Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Aug 22, 2002·Psychosomatics·Päivi A PynnönenVeikko A Aalberg
Apr 30, 2004·Statistics in Medicine·Michael J SweetingPaul C Lambert
May 12, 2004·Paediatric Respiratory Reviews·Renato T Stein, Fernando D Martinez
Jun 26, 2007·The Journal of Pediatrics·Eric A F SimoesUNKNOWN Palivizumab Long-Term Respiratory Outcomes Study Group
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Oct 22, 2010·Pediatric Pulmonology·Soren Erik PedersenUNKNOWN Global Initiative for Asthma
May 10, 2013·The New England Journal of Medicine·Maarten O BlankenUNKNOWN Dutch RSV Neonatal Network
Nov 26, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Yafang HuangAimin Guo
Oct 30, 2015·The Lancet Infectious Diseases·Katherine L O'BrienUNKNOWN Respiratory Syncytial Virus (RSV) Prevention study group
Jun 29, 2016·The Pediatric Infectious Disease Journal·Mauricio T CaballeroUNKNOWN RSV & Pediatric Asthma Working Group
Sep 24, 2016·Biochemical Pharmacology·Elisabeth HeylenDirk Jochmans
Feb 6, 2017·American Journal of Respiratory and Critical Care Medicine·Hiroyuki MochizukiUNKNOWN Scientific Committee for Elucidation of Infantile Asthma
Sep 16, 2017·Lancet·Ian D PavordAndy Bush
Mar 4, 2018·The Lancet. Respiratory Medicine·Nienke M ScheltemaLouis J Bont

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Citations

Feb 11, 2020·Journal of Leukocyte Biology·Katie M LeboldMatthew G Drake
Dec 29, 2020·Frontiers in Immunology·Sandra Axberg PålssonAnna-Lena Spetz
Mar 4, 2021·Infectious Diseases and Therapy·Michal Young, Lynn Smitherman
May 1, 2021·International Journal of Molecular Sciences·Alessandro RoccaMarcello Lanari
Aug 28, 2021·Cells·Maximilian HirschenbergerKonstantin Maria Johannes Sparrer
Aug 22, 2021·Drug Discovery Today·Anastasia ShpichkaPeter Timashev
Apr 24, 2021·The European Respiratory Journal·Anne C TeirlinckThea K Fischer

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