Association between rewarming duration and neurological outcome in out-of-hospital cardiac arrest patients receiving therapeutic hypothermia

Resuscitation
Toru HifumiJ-PULSE-Hypo Investigators

Abstract

The European Resuscitation Council guidelines recommend a slow rate of rewarming of 0.25 °C/h-0.5 °C/h for out-of-hospital cardiac arrest (OHCA) patients receiving therapeutic hypothermia (TH). Conversely, a very slow rewarming of 1 °C/day is generally applied in Japan. The rewarming duration ranged from less than 24 h up to more than 50 h. No randomized control trials have examined the optimal rewarming speed for TH in OHCA patients. Therefore, we examined the association between the rewarming duration and neurological outcomes in OHCA patients who received TH. This study was a secondary analysis of the Japanese Population-based Utstein-style study with defibrillation and basic/advanced Life Support Education and implementation-Hypothermia (J-PULSE-HYPO) study registry, a multicenter prospective cohort study. Patients suffering from OHCA who received TH (target temperature, 34 °C) after the return of spontaneous circulation from 2005 to 2011 in 14 hospitals throughout Japan were enrolled. The rewarming duration was defined as the time from the beginning of rewarming at a target temperature of 34 °C until reaching 36 °C. The primary outcome was an unfavorable neurological outcome at hospital discharge, i.e., a cerebral performa...Continue Reading

Citations

Jan 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Fabio Silvio TacconeJean-Louis Vincent
May 29, 2020·Minerva anestesiologica·Filippo AnnoniFabio S Taccone
Oct 23, 2020·Turkish Journal of Emergency Medicine·Isabelle Mullen, Benjamin S Abella
Feb 13, 2021·Resuscitation·J P NolanJ Soar
Jul 23, 2021·Nature Reviews. Neuroscience·Stefano G DanieleNenad Sestan
Oct 15, 2020·The American Journal of Emergency Medicine·Toru HifumiUNKNOWN J-PULSE-Hypo Investigators
Aug 4, 2021·Critical Care Nursing Clinics of North America·Nicole Kupchik

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