Association between rostral prefrontal cortical activity and functional outcome in first-episode psychosis: a longitudinal functional near-infrared spectroscopy study

Schizophrenia Research
Shinsuke KoikeKiyoto Kasai

Abstract

Few biomarkers can be used easily and noninvasively to measure clinical condition and future outcome in patients with first-episode psychosis (FEP). To develop such biomarker using multichannel functional near-infrared spectroscopy (fNIRS), cortical function in the prefrontal cortex was longitudinally measured during a verbal fluency task. Sixty-nine fNIRS measurements and 77 clinical assessments were obtained from 31 patients with FEP at baseline, 6-month, and 12-month follow-ups. Sixty measurements were obtained from 30 healthy controls matched for age, sex, and premorbid IQ. We initially tested signal changes for 12 months, and then investigated the relationship between fNIRS signals and clinical assessments. Signal changes from baseline to 12-month follow-up were not evident in any group. Patients with FEP had significant positive correlation coefficients between 6-month fNIRS signals and the 12-month Global Assessment of Functioning (GAF) score in the left middle frontal gyrus (FDR-corrected p=.0016-.0052, r=.65-.59). fNIRS signals at the 12-month follow-up were associated with 12-month GAF score in the bilateral superior and middle frontal gyri (FDR-corrected p=.00085-.018, r=.72-.55), and with the difference between base...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Mar 9, 2005·Archives of General Psychiatry·Rajendra A MoreyAysenil Belger
Apr 6, 2005·Archives of General Psychiatry·Jeffrey A LiebermanUNKNOWN HGDH Study Group
Sep 9, 2006·NeuroImage·Archana K Singh, Ippeita Dan
Jan 9, 2007·NeuroImage·Daisuke TsuzukiIppeita Dan
Nov 27, 2007·NeuroImage·David W ShattuckArthur W Toga
Jan 9, 2008·Archives of General Psychiatry·Tyrone D CannonRobert Heinssen
Jan 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Matthew R BroomePhilip K McGuire
Aug 13, 2009·Nature Reviews. Neuroscience·David Badre, Mark D'Esposito
Nov 3, 2010·Schizophrenia Research·Manabu KubotaToshiya Murai
Nov 18, 2010·Schizophrenia Research·M Alvarez-JimenezP D McGorry
Feb 19, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shinsuke KoikeKiyoto Kasai
Mar 24, 2011·Psychological Medicine·A HoferW W Fleischhacker
Sep 23, 2011·Schizophrenia Research·S M CottonP Conus
Mar 13, 2012·The American Journal of Psychiatry·Wenche Ten Velden HegelstadThomas McGlashan
Apr 9, 2013·BMC Psychiatry·Nasrettin SönmezJan Ivar Røssberg
Aug 16, 2013·JAMA Psychiatry·Lena PalaniyappanPaola Dazzan

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