Association Between Rotavirus Vaccination and Type 1 Diabetes in Children.

JAMA Pediatrics
Jason M GlanzFrank DeStefano

Abstract

Because rotavirus infection is a hypothesized risk factor for type 1 diabetes, live attenuated rotavirus vaccination could increase or decrease the risk of type 1 diabetes in children. To examine whether there is an association between rotavirus vaccination and incidence of type 1 diabetes in children aged 8 months to 11 years. A retrospective cohort study of 386 937 children born between January 1, 2006, and December 31, 2014, was conducted in 7 US health care organizations of the Vaccine Safety Datalink. Eligible children were followed up until a diagnosis of type 1 diabetes, disenrollment, or December 31, 2017. Rotavirus vaccination for children aged 2 to 8 months. Three exposure groups were created. The first group included children who received all recommended doses of rotavirus vaccine by 8 months of age (fully exposed to rotavirus vaccination). The second group had received some, but not all, recommended rotavirus vaccines (partially exposed to rotavirus vaccination). The third group did not receive any doses of rotavirus vaccines (unexposed to rotavirus vaccination). Incidence of type 1 diabetes among children aged 8 months to 11 years. Type 1 diabetes was identified by International Classification of Diseases codes: 25...Continue Reading

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Citations

Feb 3, 2021·American Journal of Obstetrics and Gynecology·Irene A StaffordBaha M Sibai
Apr 7, 2021·Critical Reviews in Microbiology·Ziqin DianZhijiang Miao
Aug 8, 2021·Microorganisms·Sonia R IsaacsKi Wook Kim

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