Association between self-reported questionnaire data on fertility and results of hormone analyses in women after childhood cancer: a cross-sectional study

The Journal of Obstetrics and Gynaecology Research
Andreas JantkeA Borgmann-Staudt

Abstract

The aim of this study was to compare self-reported questionnaire-based information on fertility impairment with results from hormone analyses in women who underwent chemoradiotherapy during childhood and adolescence. In a cross-sectional study, questionnaires and hormone analyses (anti-Müllerian hormone [AMH], follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone) were evaluated in 86 female former pediatric oncology patients in Berlin in 2009. Eighty-six women (median age 23 years, range 19-41) participated in the study with a median follow up of 14 years (range 2-30) after diagnosis. Among women with information on permanent and transient amenorrhea, 9% (5/55) of the women stated that they were permanently amenorrheic. Among women not taking oral contraceptives and giving information on the regularity of their menstrual cycle, 18% (4/22) had an irregular menstrual cycle and 82% (18/22) had a regular menstrual cycle. The median AMH values for women who were categorized as infertile by questionnaire-based information were significantly lower than the AMH values of women who were categorized as fertile by questionnaire (0.05 vs 2.2 ng/mL, P = 0.004). Questionnaire-based categories on the regularity of the me...Continue Reading

References

Oct 6, 2000·Fertility and Sterility·B C Fauser
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Elisabeth C LarsenAnders Nyboe Andersen
Nov 17, 2004·Menopause : the Journal of the North American Menopause Society·Ilse A J van RooijEgbert R te Velde
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jenny A VisserAxel P N Themmen
Nov 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice M WalsheSandra M Swain
Apr 5, 2008·Human Reproduction·C GnothE Godehardt
Apr 4, 2009·Fertility and Sterility·Mikkel RosendahlAnders Nyboe Andersen
Oct 31, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·K T SchmidtA N Andersen
Jun 2, 2010·Klinische Pädiatrie·R RendtorffA Borgmann-Staudt
Nov 5, 2010·Clinical Obstetrics and Gynecology·Pasquale Patrizio, Arthur L Caplan

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Citations

Apr 26, 2013·The Journal of Obstetrics and Gynaecology Research·Constanze PfitzerAnja Borgmann-Staudt
Mar 9, 2018·The Journal of Obstetrics and Gynaecology Research·Akira IwaseFumitaka Kikkawa

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