Association Between Sepsis and Microvascular Brain Injury.

Critical Care Medicine
William J EhlenbachEric B Larson

Abstract

Many survivors of sepsis suffer long-term cognitive impairment, but the mechanisms of this association remain unknown. The objective of this study was to determine whether sepsis is associated with cerebral microinfarcts on brain autopsy. Retrospective cohort study. Five-hundred twenty-nine participants of the Adult Changes in Thought, a population-based prospective cohort study of older adults carried out in Kaiser Permanente Washington greater than or equal to 65 years old without dementia at study entry and who underwent brain autopsy. Late-life sepsis hospitalization was identified using administrative data. We identified 89 individuals with greater than or equal to 1 sepsis hospitalization during study participation, 80 of whom survived hospitalization and died a median of 169 days after discharge. Thirty percent of participants with one or more sepsis hospitalization had greater than two microinfarcts, compared with 19% participants without (χ p = 0.02); 20% of those with sepsis hospitalization had greater than two microinfarcts in the cerebral cortex, compared with 10% of those without (χ p = 0.01). The adjusted relative risk of greater than two microinfarcts was 1.61 (95% CI, 1.01-2.57; p = 0.04); the relative risk for ...Continue Reading

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Feb 13, 2020·The American Journal of Psychiatry·Carsten HjorthøjMerete Nordentoft
Apr 16, 2020·Journal of the American Geriatrics Society·Robert T MankowskiFrederick A Moore
Oct 15, 2019·Critical Care Medicine·Ramona O Hopkins

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