Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Mariacristina SiottoRosanna Squitti

Abstract

Meta-analyses demonstrate copper involvement in Alzheimer's disease (AD), and the systemic ceruloplasmin status in relation to copper is an emerging issue. To deepen this matter, we evaluated levels of ceruloplasmin concentration, ceruloplasmin activity, ceruloplasmin specific activity (eCp/iCp), copper, non-ceruloplasmin copper iron, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype in a sample of 84 AD patients and 58 healthy volunteers. From the univariate logistic analyses we found that ceruloplasmin concentration, eCp/iCp, copper, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype were significantly associated with the probability of AD. In the multivariable logistic regression analysis, we selected the best subset of biological predictors by the forward stepwise procedure. The analysis showed a decrease of the risk of having AD for eCp/iCp (p = 0.001) and an increase of this risk for non-ceruloplasmin copper (p = 0.008), age (p = 0.001), and APOE-ɛ4 allele (p <  0.001). The estimated model showed a good power in discriminating AD patients from healthy controls (area under curve: 88% ; sensitivity: 66% ; specificity 93%). These data strength the breakdown of copper homeostasis and...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1992·The American Journal of Clinical Nutrition·P E JohnsonG I Lykken
Jan 1, 1988·European Neurology·B GiomettoB Tavolato
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 14, 1998·Dementia and Geriatric Cognitive Disorders·J SnaedalT Jóhannesson
Aug 15, 2000·Human Molecular Genetics·J R Forbes, D W Cox
Feb 24, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·M O LouroJ C Tutor
Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M O LouroJ C Tutor
Oct 23, 2002·Neurology·R SquittiP M Rossini
Mar 29, 2003·Annals of Clinical Biochemistry·J M Walshe, UNKNOWN Clinical Investigations Standing Committee of the Association of Clinical Biochemists
Jan 1, 1965·Annual Review of Medicine·I H SCHEINBERG, I STERNLIEB
Jan 14, 2004·Biochemistry·Craig S AtwoodAshley I Bush
Dec 23, 2004·The Journal of Laboratory and Clinical Medicine·Georgina MacintyreDiane W Cox
Jul 21, 2007·Journal of Neural Transmission·R SquittiP M Rossini
Dec 7, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Concetta R CapoLuisa Rossi
Jan 1, 1996·Archives of Gerontology and Geriatrics·M MolaschiE Ferrario
Jul 16, 2010·American Journal of Alzheimer's Disease and Other Dementias·George J BrewerRobert Dick
Oct 12, 2010·Journal of Alzheimer's Disease : JAD·Rosanna SquittiPaolo Maria Rossini
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefano OlivieriMassimo Alessio
Dec 22, 2011·Dementia and Geriatric Cognitive Disorders Extra·Gudlaug TorsdottirTorkell Jóhannesson
Feb 22, 2012·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Apr 6, 2012·Journal of Alzheimer's Disease : JAD·Mariacarla VentrigliaRosanna Squitti
Jun 8, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·George J Brewer
Sep 7, 2012·Rejuvenation Research·Rosanna SquittiPaolo Maria Rossini
Oct 6, 2012·Current Alzheimer Research·Rosanna SquittiPaolo Maria Rossini
Oct 19, 2012·Journal of Alzheimer's Disease : JAD·Natividad LópezJordi Alom
Oct 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Rachna AgarwalNeelam Chhillar
Nov 22, 2012·Journal of Alzheimer's Disease : JAD·Alan RembachAshley I Bush
Jun 14, 2013·Neuromolecular Medicine·Rosanna SquittiPaolo Maria Rossini
Jul 17, 2013·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Jun-Hyun ParkKyung Soo Park
Aug 21, 2013·Journal of Alzheimer's Disease : JAD·Serena BucossiRosanna Squitti
Sep 28, 2013·Journal of Alzheimer's Disease : JAD·Rosanna SquittiAshley I Bush

❮ Previous
Next ❯

Citations

Jun 28, 2016·Cell Biochemistry and Biophysics·Christopher E Jones, Lawrence J Berliner
Dec 17, 2016·Journal of Alzheimer's Disease : JAD·Rosanna SquittiCamillo Ricordi
Aug 9, 2016·Metallomics : Integrated Biometal Science·R SquittiL Rossi
Nov 28, 2017·Metallomics : Integrated Biometal Science·V R SamyginaV B Vasilyev
Jan 15, 2019·Alzheimer Disease and Associated Disorders·Rosanna SquittiRon Goldberg
May 10, 2019·Metallomics : Integrated Biometal Science·Courtney J McCannSvetlana Lutsenko
Jul 23, 2019·Critical Reviews in Clinical Laboratory Sciences·Peter D Fransquet, Joanne Ryan
May 9, 2018·Current Neuropharmacology·Bo Wang, Xiao-Ping Wang
Oct 11, 2017·Frontiers in Neurology·Rosanna SquittiMariacristina Siotto
May 31, 2018·Journal of Alzheimer's Disease : JAD·Rosanna SquittiRoberta Ghidoni
Feb 26, 2019·Frontiers in Neuroscience·Mariacristina SiottoFabrizio Vernieri
Feb 23, 2020·Neurobiology of Disease·Ibrahima DioufUNKNOWN Alzheimer's disease Neuroimaging Initiative
Nov 14, 2020·Journal of Alzheimer's Disease : JAD·Anastasia De LucaRosanna Squitti
Mar 9, 2021·Journal of Alzheimer's Disease : JAD·Keith W VanDusenUNKNOWN MADCO-PC Investigators
Aug 9, 2021·Biochimica Et Biophysica Acta. General Subjects·Bryce BladesSharon La Fontaine

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
atomic absorption spectrophotometry

Software Mentioned

STATA

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.