Association between Serum Cholesterol Level and Osteoporotic Fractures

Frontiers in Endocrinology
Yanmao WangYimin Chai

Abstract

Previous epidemiological studies have found an association between serum cholesterol level and bone mineral density. However, epidemiological studies evaluating the association between serum cholesterol level and the incidence of osteoporotic fracture are scant. Therefore, the objective of this study was to investigate whether serum cholesterol levels in Chinese participants aged 55 years or older was associated with an increased risk of osteoporotic fracture. We performed a cross-sectional study, including 1,791 participants (62.1% postmenopausal women and 213 fractures). Standardized self-administered questionnaires, physical examination, laboratory tests, and dual-energy X-ray absorptiometry examination were performed. Multivariate-adjusted logistic regression models were used to evaluate associations between serum cholesterol [total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C)] levels and the osteoporotic fracture risk. After adjusting for potential confounding factors, there were no associations between per SD increase in TC and LDL level and an increased risk of osteoporotic fracture in total participants, and in men and women as individual groups. There was a...Continue Reading

References

Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hoa Ton KhaFarhad Parhami
May 14, 2004·The New England Journal of Medicine·Joyce B J van MeursAndré G Uitterlinden
May 25, 2004·Expert Opinion on Pharmacotherapy·Harald Dobnig
Nov 17, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y Z BaggerUNKNOWN PERF study group
Feb 9, 2007·Pharmacoepidemiology and Drug Safety·Sengwee Toh, Sonia Hernández-Díaz
Apr 24, 2007·QJM : Monthly Journal of the Association of Physicians·E M DennisonUNKNOWN Hertfordshire Cohort Study Group
Nov 6, 2008·Bone·Joanna MakoveyPhilip N Sambrook
Dec 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Petra J BuizertElisabeth M Eekhoff
Oct 24, 2009·Endocrine Journal·José L HernándezJesus González-Macías
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pawel SzulcRoland Chapurlat
Sep 8, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P TrimpouK Landin-Wilhelmsen
Oct 27, 2010·Calcified Tissue International·In-Kyong JeongChan Soo Shin
Apr 1, 2011·Lancet·Tilman D RachnerLorenz C Hofbauer
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Andrew P SageYin Tintut
May 31, 2014·Bone·Valéria Nóbrega da SilvaJosé Eduardo Corrente
Jun 20, 2014·Indian Journal of Endocrinology and Metabolism·M K GargN Mahalle
Apr 23, 2015·Nature Reviews. Rheumatology·Gretl HendrickxWim Van Hul
Aug 8, 2015·Annals of the Rheumatic Diseases·Andréa MarquesJosé António Pereira da Silva
Sep 27, 2015·Annals of the Rheumatic Diseases·Willem F Lems
Nov 26, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L KuipersJ M Zmuda
Jun 3, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J I BarzilayK J Mukamal
Nov 27, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T AnM Zou
Dec 8, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G D ChenY M Chen
Feb 1, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicola VeroneseSarah E Lamb
Feb 2, 2017·Materia Socio-medica·Radojka BijelicSnjezana Milicevic
Feb 22, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y FengB Chen
Mar 16, 2017·Journal of the American Heart Association·Raymond B FohtungJorge R Kizer
Jul 12, 2017·The Lancet. Diabetes & Endocrinology·Sundeep Khosla, Lorenz C Hofbauer
Aug 2, 2017·Annals of Internal Medicine·Kristine E Ensrud, Carolyn J Crandall

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

PASW Statistics
SPSS
R
Empower

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.