Abstract
Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru. High Alt Med Biol 16:26-33, 2015.-Long-term residence at high altitude is associated with the development of chronic mountain sickness (CMS), which is characterized by excessive erythrocytosis (EE). EE occurs under chronic hypoxia, and a strongly selected mutation in hypoxia-inducible factor 2α (HIF2A) has been found in native Tibetans that correlates with having a normal hemoglobin at high altitude. We sought to evaluate differences in plasma levels of four HIF-responsive proteins in 20 participants with EE (hemoglobin >21 g/dL in men and >19 in women) and in 20 healthy, age- and sex-matched participants without EE living at high altitude in Puno, Peru. We performed ELISA to measure plasma levels of the four HIF-responsive proteins: vascular endothelial growth factor (VEGF), soluble VEGF receptor 1 (sVEGF-R1), endothelin-1, and erythropoietin. As a secondary aim, we evaluated the association between HIF-responsive proteins and ech...Continue Reading
References
Nov 1, 1995·The American Journal of Physiology·V S DiCarloS Oparil
Jan 15, 1995·Circulation·S GoerreW H Reinhart
Sep 1, 1994·Journal of Applied Physiology·H LiT S Elton
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Dec 1, 1996·The American Journal of Physiology·S Tjen-A-LooiI Keith
Sep 20, 1997·The Journal of Biological Chemistry·H P GerberN Ferrara
Dec 6, 2001·Circulation·B M McQuillanA E Weyman
May 10, 2003·Lancet·James R Runo, James E Loyd
Jan 17, 2004·Blood·Victor R GordeukLydia A Polyakova
Aug 3, 2005·High Altitude Medicine & Biology·Fabiola León-VelardeGustavo Zubieta-Calleja
Jun 13, 2006·High Altitude Medicine & Biology·Jim L Rupert, Michael S Koehle
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M Beall
Jun 23, 2007·The Journal of Physiology·Jorge SolizVincent Joseph
Dec 20, 2007·Journal of Cardiovascular Pharmacology·Marc Iglarz, Martine Clozel
Jan 11, 2008·The New England Journal of Medicine·Melanie J PercyFrank S Lee
May 13, 2008·Current Opinion in Pharmacology·Rubin M Tuder, Jeong H Yun
Jun 27, 2008·High Altitude Medicine & Biology·Fabiola León-Velarde, Olga Mejía
May 13, 2009·Circulation·Carolyn S P LamMargaret M Redfield
May 15, 2010·Science·Tatum S SimonsonRiLi Ge
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M BeallYong Tang Zheng
Jul 3, 2010·Science·Xin YiJian Wang
Jul 14, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Lawrence G RudskiNelson B Schiller
Mar 1, 2009·European Respiratory Review : an Official Journal of the European Respiratory Society·X-Q Xu, Z-C Jing
Nov 17, 2010·The Journal of Physiology·Wolfgang Jelkmann
Aug 13, 2011·The New England Journal of Medicine·Gregg L Semenza
Jan 14, 2012·BMJ Open·J Jaime MirandaUNKNOWN CRONICAS Cohort Study Group
Mar 1, 2012·Vascular Pharmacology·Agnieszka LobodaJozef Dulak
Dec 18, 2013·Journal of Applied Physiology·Larissa A Shimoda, Steven S Laurie
Jun 17, 2014·American Journal of Respiratory Cell and Molecular Biology·Norbert F Voelkel, Jose Gomez-Arroyo
Jun 28, 2014·High Altitude Medicine & Biology·Jose R EspinozaJean-Paul Richalet
Jul 10, 2014·Pulmonary Circulation·Victor SamillanLouise Ostergaard
Jul 10, 2014·Pulmonary Circulation·Vanesa A KaramanianPeter L Jones
Aug 19, 2014·Nature Genetics·Felipe R LorenzoJosef T Prchal
Dec 3, 2014·American Heart Journal·Maria A CaravedoUNKNOWN CRONICAS Cohort Study Group