Abstract
The aim of this study was to evaluate relationships between serum estradiol concentration and carotid atherosclerosis in addition to major cardiovascular risk factors in men with type 2 diabetes mellitus because previous reports concerning the role of estrogen on atherosclerosis in men are conflicting. Serum estradiol concentrations were measured in 305 consecutive men with type 2 diabetes mellitus. Relationships were evaluated between serum estradiol concentration and carotid atherosclerosis, as determined by ultrasonographically evaluated intima-media thickness (IMT) and plaque score, in a subgroup of 144 diabetic patients, as well as major cardiovascular risk factors, including age, blood pressure, and lipid concentrations. An inverse correlation was found between serum estradiol concentration and IMT (r = -0.174, P = .0369), but no correlation was found between serum estradiol concentration and plaque score. Patients with serum estradiol concentrations in the lowest tertile displayed significantly higher IMT compared with patients in the highest tertile (P = .0083). Serum estradiol concentration was not a determinant of IMT (beta = -.121, P = .1396) in the multiple regression analysis. An inverse correlation was found betwe...Continue Reading
References
Nov 1, 1990·Stroke; a Journal of Cerebral Circulation·N HandaT Kamada
Apr 1, 1994·Journal of Vascular Surgery·M L FoeghP W Ramwell
Apr 16, 1998·QJM : Monthly Journal of the Association of Physicians·K M EnglishK S Channer
Jun 11, 1998·Atherosclerosis·S GiriD D Waters
Aug 24, 1999·Circulation Research·L NathanG Chaudhuri
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L NathanG Chaudhuri
Apr 24, 2001·Diabetes Care·B IsomaaL Groop
May 8, 2001·Nephron·M KanauchiK Dohi
Mar 28, 2002·Diabetes·Coen D A StehouwerHans-Henrik Parving
May 27, 2003·Diabetes Care·Michiaki FukuiToshikazu Yoshikawa
Apr 21, 2004·Circulation·Majon MullerYvonne T van der Schouw
Nov 25, 2004·Diabetes Care·Michiaki FukuiToshikazu Yoshikawa
May 17, 2005·Journal of the American College of Cardiology·Juuso MäkinenOlli T Raitakari
Aug 2, 2006·Annals of Internal Medicine·Johan ArnlövRamachandran S Vasan
Citations
Jun 16, 2015·Endocrine Journal·Yi X ChanBu B Yeap
Jun 5, 2012·Atherosclerosis·Véronique SoissonPierre-Yves Scarabin
Jun 29, 2017·Medicine·Xiaoxia WangLixin Guo
Nov 4, 2017·Circulation Research·Marija GlisicTaulant Muka
Oct 18, 2019·Endocrine Journal·Simona HylmarovaMilan Kvapil
Dec 2, 2020·Current Drug Metabolism·Sangita Maiti DuttaSmarajit Maiti