Association between serum ferritin and mortality: findings from the USA, Japan and European Dialysis Outcomes and Practice Patterns Study

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Angelo KaraboyasBruce M Robinson

Abstract

The Kidney Disease: Improving Global Outcomes guidelines have cautioned against administering intravenous (IV) iron to hemodialysis patients with high serum ferritin levels due to safety concerns, but prior research has shown that the association between high ferritin and mortality could be attributed to confounding by malnutrition and inflammation. Our goal was to better understand the ferritin-mortality association and relative influence of IV iron and inflammation in the USA, where ferritin levels have recently increased dramatically, and in Europe and Japan, where ferritin levels are lower and anemia management practices differ. Data from 18 261 patients in Phases 4 and 5 (2009-15) of the international Dialysis Outcomes and Practice Patterns Study, a prospective cohort study, were analyzed. Using Cox regression, we modeled the association between baseline ferritin and 1-year mortality with restricted cubic splines and assessed the impact of potential confounders. Median ferritin levels were 718 ng/mL in the USA, 405 in Europe and 83 in Japan. High ferritin levels were associated with elevated mortality (relative to region-specific medians) in all three regions. The strength of this association was attenuated more by adjustm...Continue Reading

References

Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kamyar Kalantar-ZadehMichael H Humphreys
May 22, 2004·Journal of the American Society of Nephrology : JASN·Harold I FeldmanGerald Faich
Jul 22, 2005·Journal of the American Society of Nephrology : JASN·Kamyar Kalantar-ZadehDavid G Warnock
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Kamyar Kalantar-ZadehGrace H Lee
Dec 6, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Donald RichardsonGraham Warwick
Oct 10, 2008·Kidney International·Bradley A FordMitchell G Scott
Oct 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Mehdi RambodKamyar Kalantar-Zadeh
Nov 28, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliUNKNOWN ERA-EDTA ERBP Advisory Board
Mar 4, 2010·JAMA : the Journal of the American Medical Association·M Alan BrookhartWolfgang C Winkelmayer
Jul 9, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yoshiharu TsubakiharaTadao Akizawa
Jul 20, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·David B Van WyckResmi Gupta
Sep 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Paolo FerrariJohn K Olynyk
Aug 27, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan BazeleyBruce M Robinson
Nov 7, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Douglas S FullerBruce M Robinson
Apr 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliUNKNOWN ERA-EDTA ERBP Advisory Board
Jul 31, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alan S KligerLynda Szczech
Oct 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George R BailieBruce M Robinson
Oct 22, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Douglas S FullerBruce M Robinson
Oct 17, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Dana C MiskulinUNKNOWN Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Network Patient Outcomes in End Stage Renal Disease Stu
Dec 30, 2014·Journal of the American Society of Nephrology : JASN·David M CharytanUNKNOWN Dialysis Advisory Group of the American Society of Nephrology
May 23, 2015·Journal of the American Society of Nephrology : JASN·Itzchak Slotki, Zvi Ioav Cabantchik
Jun 23, 2015·Kidney International Supplements·Takayuki HamanoYoshiharu Tsubakihara
Aug 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Medha AiryWolfgang C Winkelmayer
May 8, 2016·Seminars in Dialysis·Jamie P Dwyer
Aug 10, 2016·Clinical and Experimental Nephrology·Tetsuo ShojiMasaaki Inaba

❮ Previous
Next ❯

Citations

Nov 14, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ruya OzelsancakHasan Micozkadioglu
Mar 4, 2019·Seminars in Dialysis·Richard A Sherman
Apr 2, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco Locatelli, Lucia Del Vecchio
Apr 5, 2019·Chinese Medical Journal·Ling-Zhi LiPing Fu
Dec 17, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jun MorinagaMasashi Mukoyama
Oct 5, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Rachel L PerlmanJeffrey Perl
Aug 19, 2020·Kidney International·Jia H NgUNKNOWN Northwell COVID-19 Research Consortium and the Northwell Nephrology COVID-19 Research Consortium
Feb 11, 2021·Clinical Kidney Journal·Takeshi Nakanishi, Takahiro Kuragano
Apr 22, 2021·Metallomics : Integrated Biometal Science·Marina PlaysRaphaël Rodriguez
Jul 1, 2021·Clinical Kidney Journal·Lucia Del VecchioUNKNOWN ERA-EDTA European Renal and Cardiovascular Medicine Working (EURECA-m) Group
Jul 3, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yukio MaruyamaTakashi Yokoo
Dec 1, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Patricia Carrilho
Jul 30, 2021·The Journal of Applied Laboratory Medicine·Ingrid Ruiz-OrdoñezGabriel J Tobón

❮ Previous
Next ❯

Software Mentioned

IVEware
SAS

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.