Association between serum folate level and cervical cancer: a meta-analysis

Archives of Gynecology and Obstetrics
Xinyue Zhou, Yuanguang Meng

Abstract

The aim of this study was to evaluate the association between serum folate level and cervical cancer. PubMed, Medline, Springer, Elsevier Science Direct, Cochrane Library and Google scholar were searched for relevant trials. Rev.Man5.1 and Stata 11.0 software were applied for this meta-analysis. Odds Ratio (OR) and 95 % confidence intervals (95 % CI) were collected and calculated in a fixed-effects model or a random-effects model when appropriate. Subgroup analysis was performed by sample size, participant's geographical location and definition of deficient serum folate level. A total of 6 case-control studies including 2383 participants were included in the meta-analysis. The overall meta-analysis showed that there were significant differences between cases and controls, suggesting that deficient serum folate level was associated with the increased risk of cervical cancer. After stratification subgroup analysis, significant difference was also found in subgroup with sample size <500 as well as in Asian population, but not in subgroup with sample size ≥500, American populations as well as different definition of deficient serum folate level (<6.4 ng/ml or others). Based on our meta-analysis, deficiency of serum folate level was...Continue Reading

References

Oct 10, 1992·Annals of the New York Academy of Sciences·C E Butterworth
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Apr 4, 2000·British Medical Bulletin·S J Duthie
Jan 5, 2002·JAMA : the Journal of the American Medical Association·N F SchlechtE L Franco
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 7, 2003·Oncogene·Richard L Momparler
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Dec 3, 2004·Cancer Research·Chandrika J PiyathilakeEdward E Partridge
Apr 28, 2007·Yonsei Medical Journal·Nemekhee OdonguaSun Ha Jee
Nov 26, 2008·Vaccine·Raul MurilloEduardo Lazcano-Ponce
Nov 26, 2008·Vaccine·Rolando HerreroJosé Jerónimo
Sep 18, 2010·BMC Health Services Research·Luz Angela Chocontá-PiraquiveFernando De la Hoz-Restrepo
Sep 4, 2012·Clinical Epigenetics·Kathleen P SaavedraJuan Carlos S Roa
Feb 14, 2013·Sexually Transmitted Diseases·Catherine Lindsey SatterwhiteHillard Weinstock
Aug 21, 2013·Archives of Gynecology and Obstetrics·Zhiqiang LiuZhilan Peng
Feb 4, 2014·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Michelle S Williams
Feb 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinchuan FangSufang Jin
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Xia BaiQin Zhou

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Citations

Oct 18, 2016·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Nicole S Carlson
Jul 5, 2016·International Journal of Molecular Sciences·Lian-Hua CuiJin-Su Choi
Oct 30, 2018·The Journal of International Medical Research·Yueying XieHaibin Yuan
Aug 14, 2018·Current Nutrition Reports·Renee PierothCarolyn Lammersfeld
Oct 31, 2020·Nutrition and Cancer·Amber NareshJennifer Cameron
Jan 2, 2021·Frontiers in Public Health·Yacong BoZengli Yu
Sep 23, 2019·European Journal of Pharmacology·Mengting ZhaoQinjie Weng
Feb 4, 2021·International Journal of Molecular Sciences·Marta WoźniakSiddarth Agrawal
Dec 9, 2020·Nutrients·Kaja Michalczyk, Aneta Cymbaluk-Płoska
Mar 19, 2021·The Journal of Infectious Diseases·Hui-Yi LinMichael E Hagensee

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