Association between serum haptoglobin and the pathogenesis of Alzheimer's disease

Internal Medicine
In-Uk SongHyun-Ji Cho

Abstract

Haptoglobin (Hpg) is known to have several functional properties, including antioxidant and anti-inflammatory activities. In addition, it has been shown that the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease (AD), involves inflammation as well as oxidative stress. However, evidence suggesting an association between the serum Hpg level and AD is lacking. Therefore, we conducted this study in order to investigate whether serum Hpg is associated with AD. We compared the serum Hpg levels of 121 patients with newly diagnosed AD, 58 patients with Parkinson's disease (PD) and 43 healthy controls. We also evaluated the relationship between the severity of cognitive impairment in patients with AD and the serum Hpg level. The mean serum Hpg level of the patients with AD was significantly higher than that of the healthy controls (p=0.042), although it was not significant different from that observed in the PD group (p=0.613). We also found a significant positive association between the serum Hpg level and the severity of cognitive impairment, as measured using several neuropsychological tests, in the patients with AD. The odds ratio (95% confidence interval) of the patients with AD grouped according to the Hpg l...Continue Reading

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Citations

Oct 29, 2015·BioMed Research International·Alan KirwanMichelle Kilcoyne
Sep 21, 2018·Pharmaceuticals·Veronica FioritoEmanuela Tolosano
Jan 18, 2020·International Journal of Molecular Sciences·David CohenXudong Huang
Sep 11, 2020·Journal of Neurochemistry·Jessica Diniz PereiraKarina Braga Gomes
Oct 25, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Félix Javier Jiménez-JiménezJosé A G Agúndez
Feb 3, 2021·The American Journal of the Medical Sciences·John K MaesakaWayne D Comper
Jul 15, 2020·Molecular Aspects of Medicine·Alessandra di MasiPaolo Ascenzi
May 1, 2021·International Journal of Molecular Sciences·Tânia Soares MartinsAna Gabriela Henriques
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