Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Rui Wang, Hongyan Liu

Abstract

Irisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes' Library, China National Knowledge Infrastructure, and WanFang databases from inception to December 5, 2020. A random-effects model or a fixed-effects model was used to pool the results according to the heterogeneity. Overall, thirteen matched case-control studies including 1735 T2DM patients were included. Results of meta-analysis showed that compared to T2DM patients with normoalbuminuria, those with microalbuminuria [10 studies, standard mean difference (SMD): 1.12, 95% confidence interval (CI): 0.48-1.77, p<0.001; I2=94%] and macroalbuminuria (10 studies, SMD: 1.86, 95% CI: 0.93-2.79, p<0.001; I2=97%) had significantly lower serum irisin. Besides, the serum level of irisin was significantly lower in T2DM patients with macroalbuminuria than those with microa...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 27, 2009·Nature Reviews. Nephrology·George JerumsRichard J MacIsaac
Dec 18, 2013·Journal of Diabetes and Its Complications·Jian-Jun LiuSu Chi Lim
Jan 28, 2015·Journal of Diabetes and Its Complications·Hao-hua WangQiao-qiong Chen
Mar 31, 2015·Annals of Clinical Biochemistry·Wenchao HuWenhui Wang
Jun 15, 2016·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·X-L DuZ-T Lv
Nov 4, 2016·The Korean Journal of Internal Medicine·Jin Joo ChaYoung Sun Kang
Feb 18, 2017·Nature Reviews. Endocrinology·Nikolaos PerakakisChristos S Mantzoros
Sep 7, 2017·Current Diabetes Reviews·Salah ShelbayaMagdy Abbas
Nov 25, 2017·Endocrine·Stergios A PolyzosChristos S Mantzoros
Mar 1, 2018·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Chih LinTzong-Shinn Chu
Aug 1, 2019·World Journal of Clinical Cases·Jue JiaYong-Qin Shi
Aug 9, 2019·Indian Journal of Clinical Biochemistry : IJCB·Ramalingam MageswariK V Vinod
Aug 25, 2019·Medicina·Paulina KortaAgnieszka Mazur-Biały
Nov 23, 2019·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Magdalena MaciorkowskaJolanta Małyszko
Nov 27, 2019·Molecular Metabolism·Haiyan FuDong Zhou
Apr 7, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Yuxue LiuZheng Dong
Apr 9, 2020·Diabetes, Obesity & Metabolism·Nicholas M Selby, Maarten W Taal
Oct 3, 2020·International Journal of Molecular Sciences·Kyeongho Byun, Sewon Lee
Oct 31, 2020·Primary Care·Ryan BonnerAshish Upadhyay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved