Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study

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Aida SantaolallaMieke Van Hemelrijck

Abstract

Background: Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral immune markers remains unclear. Thus, we explored the reciprocity between the humoral immune system and inflammation and assessed how external socio-demographic factors influence these interactions.Methods: From the AMORIS cohort, 5,513 individuals were identified with baseline measurements of serum humoral immune (immunoglobulin G, A & M) and inflammation (CRP, albumin, haptoglobin, white blood cells, iron & total iron-binding capacity) markers measured on the same day. Correlation analysis, principal component analysis and hierarchical clustering were used to evaluate biomarkers correlation, variation and associations. Multivariate analysis of variance was used to assess associations between biomarkers and educational level, socio-economic status, sex and age.Results: Frequently used serum markers for inflammation, CRP, haptoglobin and white blood cells, correlated together. Markers of the humoral immune system, immunoglobulin A and G, also correlated together. Hierarchical clustering and principal component analysis confirmed the interaction between these ma...Continue Reading

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