Association between serum Na-Cl level and renal function decline in chronic kidney disease: results from the chronic kidney disease Japan cohort (CKD-JAC) study

Clinical and Experimental Nephrology
Yuichi MarutaAkira Hishida

Abstract

Metabolic acidosis, which reduces serum bicarbonate levels, contributes to the progression of chronic kidney disease (CKD). The difference between sodium and chloride (Na-Cl) may theoretically predict serum bicarbonate levels. This study aimed to evaluate serum Na-Cl level as a risk factor for renal function decline among patients who participated in the chronic kidney disease Japan cohort (CKD-JAC) study. The association between low Na-Cl concentration (< 34 mmol/L) and composite renal function decline events (any initiation of renal replacement therapy or 50% decline in estimated glomerular filtration rate) was evaluated among 2143 patients with CKD stage G3a-4. Using Cox regression analysis, hazard ratios (HRs) were estimated after adjusting for the following covariates: age, sex, diabetes mellitus, diabetic nephropathy, cardiovascular disease, anemia, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists, loop diuretics, cigarette smoking, body mass index, serum albumin, systolic blood pressure, urine albumin-to-creatinine ratio, and CKD stage. Composite renal function decline events were observed in 405 patients (18.9%) over the 4-year follow-up period. Low serum Na-Cl level (< 34 mmol/L) was ind...Continue Reading

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References

Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A NathT H Hostetter
Oct 9, 1980·The New England Journal of Medicine·P A GabowR W Schrier
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey A Kraut, Ira Kurtz
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Enyu ImaiUNKNOWN CKD-JAC Study Group
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samir N ShahMichal L Melamed
Jul 18, 2009·Journal of the American Society of Nephrology : JASN·Ione de Brito-AshurstMuhammad M Yaqoob
Dec 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Karen H van HoevenDavid S Siegel
May 25, 2012·Kidney International·Matthew K AbramowitzMichal L Melamed
Feb 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Nimrit GorayaDonald E Wesson
Mar 16, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mirela DobreUNKNOWN CRIC Investigators
Aug 26, 2014·Journal of the American Society of Nephrology : JASN·Mirela DobreThomas H Hostetter
Mar 14, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan HavlinOtto Schück

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Citations

Feb 12, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ming-Juan ZhaoXian-Tao Zeng
Jan 8, 2021·Clinical and Experimental Nephrology·Kenichi TanakaJunichiro J Kazama
Mar 30, 2021·Frontiers in Nutrition·Chi H ChanJaimon T Kelly

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