Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth

The Journal of Clinical Endocrinology and Metabolism
Tilman WitteHenry Völzke

Abstract

No studies have examined the association between TSH and lipid profiles of healthy children and adolescents in the general population. The objective was to investigate the association between TSH and lipid profiles. We used a population-based cross-sectional study design and analyzed our results using multivariable regression models. The study was conducted in Germany. We analyzed data from 6622 children (ages 3-10 y) and 6134 adolescents (ages 11-17 y) drawn from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Not applicable. Blood samples were collected, and serum TSH levels were measured using the electrochemiluminescence method. High and low serum TSH levels were defined according to age-specific reference limits for the assay. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels were determined with enzymatic color analyses. We found a significant positive association between TSH and all non-HDL parameters (total cholesterol, LDL-C, and triglycerides) in children (β = 0.90, 95% confidence interval [CI], 0.53-1.27; β = 0.78, 95% CI, 0.44-1.13; and β = 0.90, 95% CI, 0.52-1.27, respectively) and in adolesc...Continue Reading

Citations

Dec 10, 2015·Thyroid : Official Journal of the American Thyroid Association·Till IttermannMarcus Dörr
Apr 14, 2016·European Journal of Endocrinology·Manuela CerboneMariacarolina Salerno
Nov 4, 2016·Nature Reviews. Endocrinology·Mariacarolina SalernoFilippo De Luca
Jul 19, 2016·Advances in Pediatrics·Janiel PimentelChirag Kapadia
Aug 4, 2016·Scientific Reports·Jesse RijksAnita Vreugdenhil
Sep 8, 2016·Thyroid : Official Journal of the American Thyroid Association·Trang N LeEdmond P Wickham
Apr 6, 2017·The Journal of Clinical Endocrinology and Metabolism·Jesse M RijksAnita C E Vreugdenhil
Jun 8, 2018·Critical Reviews in Clinical Laboratory Sciences·Houman TahmasebiKhosrow Adeli
May 31, 2018·Clinical Endocrinology·Amanda R DahlSeema Kumar
Jun 7, 2019·Childhood Obesity·Aris GiannakopoulosChristina Kanaka-Gantenbein
Jun 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José María Moreno-NavarreteJosé Manuel Fernández-Real
Jan 11, 2020·Frontiers in Endocrinology·Rade VukovicJelena Vekic
May 28, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anoop Mohamed IqbalSeema Kumar

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