Association Between Shigella Infection and Diarrhea Varies Based on Location and Age of Children

The American Journal of Tropical Medicine and Hygiene
Brianna LindsayOscar Colin Stine

Abstract

Molecular identification of the invasion plasmid antigen-H (ipaH) gene has been established as a useful detection mechanism for Shigella spp. The Global Enteric Multicenter Study (GEMS) identified the etiology and burden of moderate-to-severe diarrhea (MSD) in sub-Saharan Africa and south Asia using a case-control study and traditional culture techniques. Here, we used quantitative polymerase chain reaction (qPCR) to identify Shigella spp. in 2,611 stool specimens from GEMS and compared these results to those using culture. Demographic and nutritional characteristics were assessed as possible risk factors. The qPCR identified more cases of shigellosis than culture; however, the distribution of demographic characteristics was similar by both methods. In regression models adjusting for Shigella quantity, age, and site, children who were exclusively breast-fed had significantly lower odds of MSD compared with children who were not breast-fed (odds ratio [OR] = 0.47, 95% confidence interval (CI) = 0.28-0.81). The association between Shigella quantity and MSD increased with age, with a peak in children of 24-35 months of age (OR = 8.2, 95% CI = 4.3-15.7) and the relationship between Shigella quantity and disease was greatest in Bang...Continue Reading

References

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Sep 18, 2013·The Journal of Infectious Diseases·Mami TaniuchiEric R Houpt
Jan 28, 2015·Emerging Infectious Diseases·Brianna LindsayO Colin Stine

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Citations

Dec 9, 2016·The American Journal of Tropical Medicine and Hygiene·Ibrahim KhalilAli H Mokdad
Feb 5, 2016·The American Journal of Tropical Medicine and Hygiene·Iruka N OkekeJapheth A Opintan
Feb 5, 2016·The American Journal of Tropical Medicine and Hygiene·James Nataro, O Colin Stine
Aug 5, 2017·International Journal of Public Health·UNKNOWN GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators
Nov 10, 2017·Journal of Clinical Microbiology·Jie LiuEric Houpt
May 26, 2018·Beneficial Microbes·G ReidW Sybesma
Nov 1, 2016·Clinical and Vaccine Immunology : CVI·Wilbur H Chen, Karen L Kotloff
Mar 27, 2020·International Journal of Environmental Research and Public Health·Ruixue LiYuantao Hao

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