Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.

BMC Medical Genetics
Cindy L EhlersKirk C Wilhelmsen

Abstract

Variation in response to the hedonic and adverse effects of a substance is in part an inherited factor that may influence its use, abuse and dependence. The mu opioid receptor is the primary site of action for opiates and individuals with polymorphisms in this receptor appear to have variation in the CNS effects of opiates. Several studies have suggested that this receptor may also mediate some of the effects of non-opioid drugs, such as alcohol. The purpose of this study was to investigate associations between 13 single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) with self-reported responses to alcohol, an endophenotype associated with the development of alcohol dependence, in American Indians living on eight contiguous reservations. Each participant gave a blood sample and completed a structured diagnostic interview. Additionally, response to alcohol was indexed using the expectation version of the subjective high assessment scale (SHAS-E). SNPs were genotyped in 251 participants and data analyses were conducted using SOLAR. The estimated heritability (h2) for the SHAS-E phenotypes ranged from 0.01 to 0.28. Endorsing the expectation of a more intense response on one or more of the following items from the ...Continue Reading

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Citations

May 2, 2012·Human Genetics·Orna LevranMary Jeanne Kreek
Apr 15, 2010·Journal of Addictive Diseases·Ian R GizerKirk C Wilhelmsen
May 28, 2010·Psychiatric Genetics·Cindy L EhlersKirk C Wilhelmsen
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Methods Mentioned

BETA
pharmacotherapy
Pharmacotherapies
PCR
genotyping

Software Mentioned

PEDSTATS
PHYLIP
SOLAR
Haploview

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