Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Kimberly E AlexanderMonika Janda

Abstract

Improved survival for men with prostate cancer has led to increased attention to factors influencing quality of life (QOL). As protein levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) have been reported to be associated with QOL in people with cancer, we sought to identify whether single-nucleotide polymorphisms (SNPs) of these genes were associated with QOL in men with prostate cancer. Multiple linear regression of two data sets (including approximately 750 men newly diagnosed with prostate cancer and 550 men from the general population) was used to investigate SNPs of VEGF and IGF-1 (10 SNPs in total) for associations with QOL (measured by the SF-36v2 health survey). Men with prostate cancer who carried the minor 'T' allele for IGF-1 SNP rs35767 had higher mean Role-Physical scale scores (≥0.3 SD) compared to non-carriers (p < 0.05). While this association was not identified in men from the general population, one IGF-1 SNP rs7965399 was associated with higher mean Bodily Pain scale scores in men from the general population that was not found in men with prostate cancer. Men from the general population who carried the rare 'C' allele had higher mean Bodily Pain scale scores (≥0.3 SD...Continue Reading

References

Jan 1, 1990·Epidemiology·K J Rothman
Oct 28, 1999·PharmacoEconomics·S D Sommers, S D Ramsey
Sep 12, 2001·World Journal of Urology·B DjavanM Marberger
Nov 15, 2002·Molecular and Cellular Endocrinology·R J A van Moorselaar, E E Voest
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jeffrey A MeyerhardtCharles S Fuchs
Oct 11, 2005·Lancet·Andrew T Hattersley, Mark I McCarthy
Oct 15, 2005·Medical Care·James C RomeisWilliam R True
Jan 19, 2006·Journal of the National Cancer Institute·Iona ChengMatthew L Freedman
Jun 6, 2006·Psychological Medicine·R B NesT Reichborn-Kjennerud
Jun 27, 2006·Social Science & Medicine·Ida Joanna KorfageMarie-Louise Essink-Bot
Feb 3, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Graeme HawthorneJan Sansoni
Aug 11, 2007·International Journal of Radiation Oncology, Biology, Physics·Christopher A PetersBarry S Rosenstein
May 22, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Mirjam A G SprangersAilko H Zwinderman
Dec 31, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunichi Namiki, Yoichi Arai
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Sep 14, 2010·Gynecologic Oncology·Felicity LoseAmanda B Spurdle
Oct 15, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mirjam A G SprangersUNKNOWN GENEQOL Consortium
May 13, 2011·Breast Cancer Research and Treatment·Biyun QianKexin Chen
Jun 2, 2011·Disease Models & Mechanisms·Sebastien ElisShoshana Yakar
Jul 12, 2011·Urologic Oncology·Felicity LoseUNKNOWN Australian Prostate Cancer BioResource
Nov 23, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tanja LangsenlehnerUwe Langsenlehner
May 1, 2012·Seminars in Oncology Nursing·Christine Miaskowski, Bradley E Aouizerat
Aug 22, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tanja LangsenlehnerUwe Langsenlehner
Jul 16, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Sigal Ben-ZakenAlon Eliakim
Mar 8, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mirjam A G SprangersJeff A Sloan

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