Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort

Journal of Dermatological Science
Ana BatallaPablo Coto-Segura

Abstract

The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO). To determine whether the variation at the IL17 pathway genes was linked to the risk for PsO or had an effect on disease severity and the risk for Psoriatic arthritis (PsA). Cross-sectional observational study of 580 psoriasis patients and 567 healthy controls who were genotyped for six single nucleotide polymorphisms (SNPs) in the IL17RA (rs4819554, rs879577), IL17A (rs7747909), IL17F (rs763780, rs2397084), and IL17E (rs79877597) genes. We found significant higher frequencies of IL17RA rs4819554 G carriers among the patients (OR=1.33, 95%CI=1.05-1.69; p=0.017). The IL17RA rs4819554 G allele and IL17F rs2397084 TT genotype were significantly more frequent among Cw6 positive patients (p=0.037 and p=0.010, respectively). The IL17E rs79877597C allele was significantly more common among patients with severe forms of PsO (p=0.010; OR=2.42, 95%CI=1.23-4.76), and the CC genotype with the presence of arthritis (p=0.032; OR=1.50, 95%CI=1.04-2.18). We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.

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Citations

Jun 23, 2016·The Journal of Investigative Dermatology·Luisa SenraNicolò Costantino Brembilla
Sep 28, 2016·The Pharmacogenomics Journal·A BatallaP Coto-Segura
Oct 4, 2016·International Journal of Dermatology·Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Aug 7, 2017·Clinical Reviews in Allergy & Immunology·Wolf-Henning Boehncke, Nicolo Costantino Brembilla
Aug 7, 2019·Experimental and Therapeutic Medicine·Alexandra Dana PușcașRemus Ioan Orăsan
Aug 22, 2018·Frontiers in Immunology·Nicolo Costantino BrembillaWolf-Henning Boehncke
Sep 25, 2020·Journal of Cosmetic Dermatology·Hesham NadaMona A Atwa
Jan 25, 2021·The Journal of Allergy and Clinical Immunology·Julia BorowczykWolf-Henning Boehncke
May 1, 2021·Journal of Personalized Medicine·Cristina Membrive JiménezAlberto Jiménez Morales
Oct 28, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Fridha Viridiana Villalpando-VargasOmar Graciano-Machuca

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