Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study

Medicine
Zhi-Jun DaiXi-Jing Wang

Abstract

DNA polymerases are responsible for ensuring stability of the genome and avoiding genotoxicity caused by a variety of factors during DNA replication. Consequently, these proteins have been associated with an increased cancer risk. DNA polymerase kappa (POLK) is a specialized DNA polymerase involved in translesion DNA synthesis (TLS) that allows DNA synthesis over the damaged DNA. Recently, some studies investigated relationships between POLK polymorphisms and cancer risk, but the role of POLK genetic variants in breast cancer (BC) remains to be defined. In this study, we aimed to evaluate the effects of POLK polymorphisms on BC risk.We used the Sequenom MassARRAY method to genotype 3 single nucleotide polymorphisms (SNPs) in POLK (rs3213801, rs10077427, and rs5744533), in order to determine the genotypes of 560 BC patients and 583 controls. The association of genotypes and BC was assessed by computing the odds ratio (OR) and 95% confidence intervals (95% CIs) from logistic regression analyses.We found a statistically significant difference between patient and control groups in the POLK rs10077427 genotypic groups, excluding the recessive model. A positive correlation was also found between positive progesterone receptor (PR) st...Continue Reading

References

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Citations

Dec 22, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Xu GaoHermann Brenner
Apr 24, 2018·Cell Cycle·Yang YangCyrus Vaziri
Sep 16, 2018·International Journal of Clinical Oncology·Xu LiuJikui Liu
Jun 20, 2019·Current Molecular Medicine·Ying WeiXinhan Zhao
Jun 24, 2020·Breast Cancer Research and Treatment·Ying WeiXinhan Zhao
Oct 28, 2019·Bioscience Reports·Ming ZhangYuan Wu
Oct 20, 2017·The Journal of Gene Medicine·Tianbo JinDaoke Yang
Aug 9, 2020·Lipids in Health and Disease·Peng QianGairong Huang
Aug 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hannah R SternPenny J Beuning
Dec 8, 2020·Clinical Breast Cancer·Wei YangDongya Yuan
Sep 8, 2016·Chemical Research in Toxicology·Jae-Kwon KimJeong-Yun Choi
Jul 14, 2018·Chemical Research in Toxicology·Nicole M AntczakPenny J Beuning

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Methods Mentioned

BETA
Assay
genotyping

Software Mentioned

Sequenom MassARRAY Assay Design
SPSS
Sequenom Typer

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