Association between smoking habits and tryptophan hydroxylase gene C218A polymorphism among the Japanese population.

Journal of Epidemiology
Shoichi MizunoKazuo Tajima

Abstract

Genetic polymorphisms have proposed a new insight in smoking behavior. Genes in serotonin system are one of the candidates because of serotonin's role in mood regulation. A polymorphism C218A in intron 7 of the tryptophan hydroxylase (TPH) gene has been hypothesized in relation to smoking predisposition. We examined the association on two Japanese populations: one was from the first-visit outpatients of Aichi Cancer Center Hospital during 3-month period between April and June, 2001 (N=591), and the second was from the examinees who attended a health checkup program supported by the Nagoya municipal government in 2000 (N=446). Written documents on informed consent were obtained and lifestyle questionnaires were recorded. TPH C218A genotypes were determined by the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method. The frequencies of the C- and A-allele were 52% and 48%, respectively, which was in Hardy-Weinberg equilibrium. As for current smoking status, no associations were statistically observed. It was, however, indicated that smokers with A/A genotype started smoking earlier in their life. Among male health examinees, mean ages at starting smoking were 18.7 (A/A), 19.9 (C/A), and 22.4 years (C/C), ...Continue Reading

References

Sep 1, 1991·British Journal of Addiction·T F HeathertonK O Fagerström
Sep 30, 2000·Japanese Journal of Cancer Research : Gann·N HamajimaK Tajima
Dec 6, 2000·Progress in Brain Research·D E Comings, K Blum
Jul 4, 2001·Journal of Epidemiology·N HamajimaK Tajima
Aug 10, 2001·American Journal of Medical Genetics·C LermanP G Shields
May 3, 2002·The Journal of Molecular Diagnostics : JMD·Nobuyuki HamajimaKazuo Tajima
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
Feb 4, 2003·Pharmacogenetics·Hidemi ItoKazuo Tajima
May 13, 2003·Chest·Vikas BatraFrank T Leone
Jun 11, 2003·Annals of Medicine·Rachel F Tyndale

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