PMID: 26770393Jan 16, 2016Paper

Association between sodium iodide symporter and differentiated Thyroid cancer: a meta-analysis of 9 studies

International Journal of Clinical and Experimental Medicine
Rui ZhangJianjun Dong

Abstract

As many studies proved that sodium iodide symporter (NIS) plays a key role in radioactive iodide (RAI) therapy of thyroid cancer, however, a growing number of studies suggests that part of differentiated thyroid carcinomas (DTC) with overexpression of NIS are insensitive to RAI well. The aim of this meta-analysis is to assess the expression of NIS in differentiated thyroid cancer, compared with normal thyroid tissue. PUBMED, Sinomed, CNKI, Wanfang and VIP were searched for relevant case-control studies up to now. Studies that concerning the qualitative expression NIS in DTC were included. Working independently, authors used a standard form to extract data. For quality assessment, Newcastle-Ottawa Scale (NOS) were applied. Totally nine eligible studies included, involving 765 cases and 473 controls. The results revealed that the expression of NIS had a statistically increased in DTC, compared with controls (OddsRadio OR: 1.47, 95% CI: 1.12 to 1.94, Z=2.78, P=0.005). Since the existence of the significant heterogeneity, subgroup analysis and sensitivity analysis were performed and found that the heterogeneity came from the different criteria evaluate positive NIS expression (Liu 2008, Mu 2010) and the small simple size of the con...Continue Reading

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