Association Between Staphylococcus aureus Bacteremia and Hospital Mortality in Hemodialysis Patients With Bloodstream Infection: A Multicenter Cohort From Japanese Tertiary Care Centers

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Takahiro ImaizumiYoshiro Fujita

Abstract

Multiple studies have shown that Staphylococcus aureus bacteremia (SAB) has been a major cause of death in hemodialysis patients. We examined whether SAB is a risk for mortality among chronic hemodialysis patients in Japan where the standard vascular access is arteriovenous fistula (AVF). This was a multicenter, retrospective study of maintenance hemodialysis patients with bloodstream infection (BSI) from 2011 to 2013 at tertiary care centers in Japan. The endpoint was hospital mortality. Our cohort contained 32 SAB cases (14 MRSA and 18 MSSA) and 42 non-SAB cases. Hospital mortality was higher among SAB cases than non-SAB cases (46.9% vs. 23.8%, P = 0.038). In patients with BSI, SAB was significantly associated with hospital mortality after adjustment for potential confounders, including type of vascular access (OR 3.26). S. aureus was the leading cause of BSI and hospital mortality among this cohort. Therefore, initial empiric treatment should cover for S. aureus.

References

Apr 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M P WeinsteinL B Reller
Jan 9, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Margaret DopirakBrian Cooper
Apr 9, 2004·Critical Care Medicine·Kevin B LauplandDeirdre L Church
May 22, 2004·American Journal of Infection Control·Geoffrey TaylorUNKNOWN Canadian Hospital Epidemiology Committee
Jan 31, 2006·Hemodialysis International·Mark D DaneseAllen R Nissenson
Oct 17, 2006·Clinical Microbiology Reviews·Keri K Hall, Jason A Lyman
Feb 7, 2008·Seminars in Dialysis·R Monina KlevensUNKNOWN NHSN Participants in Outpatient Dialysis Surveillance
May 31, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jean EthierRonald L Pisoni
Sep 2, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jean-Philippe LafranceSameena Iqbal
Jun 18, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Priti R PatelMatthew J Arduino
Aug 31, 2010·The American Journal of Medicine·Brian C PienMelvin P Weinstein
Aug 21, 2012·Journal of the American Society of Nephrology : JASN·Kevin E ChanRaymond M Hakim
Nov 20, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hui XueEduardo Lacson
Feb 11, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ronald L PisoniBruce M Robinson
Jan 16, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ikuto MasakaneKosaku Nitta

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Related Papers

The International Journal of Artificial Organs
Radojica V StolicGordana Subaric-Gorgieva
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Vanessa GrubbsKirsten L Johansen
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Carolyn Guertin McHugh, Lee W Riley
© 2022 Meta ULC. All rights reserved