Association Between Statin Use and Sex Hormone in the Multi-Ethnic Study of Atherosclerosis Cohort

The Journal of Clinical Endocrinology and Metabolism
Oludamilola W OluleyeSuma H Konety

Abstract

Based on the 2018 American College of Cardiology/American Heart Association cholesterol guidelines, the number of individuals eligible for statin therapy to reduce atherosclerotic cardiovascular disease risk has greatly expanded. Statins inhibit cholesterol biosynthesis, which can impair gonadal steroidogenesis. We evaluated the effect of statins on endogenous sex hormones in a large epidemiological study. A total of 6814 Multi-Ethnic Study of Atherosclerosis (MESA) participants underwent the baseline examination. Of these, 6171 had measurements of serum sex hormones available: dehydroepiandrosterone (DHEA), SHBG, estradiol, and total and bioavailable testosterone. Multivariable linear regression models were used to assess the relationship of statin use with each sex hormone. A total of 345 women (17.4%) and 464 men (14.7%) were statin users (mean age, 67 years; 41% white, 29% black, 11% Chinese, and 19% Hispanic). Among the users vs nonusers of statins, the mean SHBG was 3.54 nmol/L (P < 0.01) lower in women and 3.37 nmol/L (P < 0.001) lower in men; the mean DHEA was 1.06 nmol/L (P < 0.05) lower in women and 0.70 nmol/L (P < 0.01) lower in men, after adjustment for potential confounders. With further propensity score adjustmen...Continue Reading

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Citations

Feb 11, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Edra LondonConstantine A Stratakis
Jan 22, 2021·The Annals of Pharmacotherapy·Giuseppe Famularo, Cesare Sarrecchia
May 28, 2021·Cancer Causes & Control : CCC·David S LopezKyriakos Markides
Jun 22, 2021·International Journal of Endocrinology·João Martin MartinsCatarina Mota
May 21, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·In Gab JeongChoung-Soo Kim
Nov 24, 2020·European Journal of Pharmacology·Cosimo Andrea StamerraAmirhossein Sahebkar

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