Association between steatohepatitis biomarkers and hepatocellular carcinoma after hepatitis C elimination

Alimentary Pharmacology & Therapeutics
E OgawaKazuhiro Toyoda

Abstract

A strong association between chronic hepatitis C (CHC) and hepatic steatosis has been reported. However, the influence of steatohepatitis on hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) elimination remains unclear. To evaluate the development of HCC after HCV cure using a new steatohepatitis-related biomarker. This cohort study analysed the prospective database of 290 CHC patients without a history of HCC who achieved HCV elimination by direct-acting antivirals. We calculated the FibroScan-aspartate aminotransferase (FAST) score 12 weeks after the end of treatment (pw12). The risk of HCC was analysed using the multivariable Cox proportional hazard model. HCV genotype (GT)1 was most prevalent at 72.4%, followed by GT2 (26.6%). Median follow-up period was 4.2 years (IQR 3.1-4.5). The cumulative HCC incidence for a FAST score ≥ 0.35 was significantly higher than that for a FAST score < 0.35 (log-rank test: P < 0.001). The annual HCC incidence rate for a FAST score ≥ 0.35 was significantly higher than that for a FAST score < 0.35, in patients with liver stiffness measurement (LSM) ≥10 kPa (adjusted hazard ratio [HR] 4.41, 95% confidence interval [CI] 1.30-15.0, P = 0.018). After adjusting for variables, including ag...Continue Reading

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Citations

Dec 2, 2020·Journal of Clinical Medicine·Naoto KubotaYujin Hoshida
Dec 5, 2020·Journal of Hepatology·Francesco Negro
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Aug 11, 2021·Journal of Gastroenterology and Hepatology·Eiichi OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Sep 3, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takumi KawaguchiTakuji Torimura

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