Association between Subclinical Low Serum 25(OH)D in Donors and Fatty Liver Disease in Recipients after Living Donor Liver Transplantation

BioMed Research International
King-Wah ChiuChao-Long Chen

Abstract

To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction. We measured the serum 25(OH)D concentrations and investigated the CYP2R1 and VDR genotypes of the donors and recipients before and after LDLT for comparison with the histological findings from the donors on wedge biopsy, the recipients' removed native liver, and selective liver biopsy after LDLT. There was a significant difference in low serum 25(OH)D concentration between the donors and recipients before LDLT and in the recipients before versus after LDLT (13.90 ± 8.85 versus 47.9 ± 14.88 versus 11.82 ± 10.36, P < 0.001), and significant difference in FLD was detected on wedge biopsy from the donors and the native liver from the recipients as well as the native liver and follow-up biopsy from the recipients (P < 0.001). CYP2R1 and VDR genotype were predominant, both for the AG and for the GG alleles. For the donor VDR SNP rs2228570, low seru...Continue Reading

References

Feb 14, 2007·Transplantation·Koji YamamotoKoichi Tanaka
Feb 18, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Salvatore PettaAntonio Craxí
Jul 24, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Davide BitettoPierluigi Toniutto
Sep 15, 2011·European Journal of Clinical Investigation·King-Wah ChiuChao-Long Chen
Jul 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ilaria BarchettaMaria Gisella Cavallo
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harald FarnikChristian M Lange
May 23, 2014·Transplantation·Yu-Fan ChengChao-Long Chen
Nov 27, 2014·Immunologic Research·Nancy Agmon-LevinYehuda Shoenfeld
May 16, 2015·Journal of Biomedical Science·King-Wah ChiuChao-Long Chen
Jun 24, 2017·Metabolism: Clinical and Experimental·Isabella RecciaDuncan Spalding

❮ Previous
Next ❯

Citations

Jun 24, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·King-Wah ChiuChao-Long Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
Enzyme-Linked Immunosorbent Assay

Software Mentioned

Statistical Package for the Social Sciences

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.