Association between subjective memory assessment and associative memory performance: Role of ad risk factors

Psychology and Aging
Marci M HornKaren M Rodrigue

Abstract

Decline in associative memory abilities is a common cognitive complaint among older adults and is detectable in both normal aging and in prodromal Alzheimer's disease (AD). Subjective memory (SM) complaints may serve as an earlier marker of these mnemonic changes; however, previous research examining the predictive utility of SM to observed memory performance yielded inconsistent results. This inconsistency is likely due to other sources of variance that occur with memory decline such as mood/depression issues, presence of apolipoprotein E (APOE ε4) genotype, or beta-amyloid deposition. Here we examine the relationship between SM and associative memory ability in the context of factors that increase susceptibility to AD in 195 healthy adults (79 men) aged 20-94 years. Participants completed an SM questionnaire, a mood/depression scale, two associative memory tests (a word-pair and a name-face test), and were genotyped for APOE ε4. PET-amyloid imaging data were collected for a subset of those over 50 years of age (N = 74). We found that SM predicted performance on both associative memory tests even after covarying for age, sex, mood, and APOE ε4 status. Interestingly, for the name-face associative task, increased SM concerns pre...Continue Reading

Citations

Jul 16, 2019·Journal of Alzheimer's Disease : JAD·Tiago MendesAlexandre de Mendonça
Feb 28, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Xi ChenDenise C Park
Sep 6, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Hui YuLi-Li Yuan
Sep 21, 2021·Journal of Clinical and Experimental Neuropsychology·Juan Francisco Flores VazquezPilar Andrés

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