Association Between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography

Investigative Ophthalmology & Visual Science
Mingui KongYun-Mi Song

Abstract

This study aimed to evaluate an association between hypertension and macular thickness. A total of 827 Korean adults composed of 163 pairs of twins and their family members were included in this population-based cross-sectional study. Macular thickness was measured with optical coherence tomography at nine macular subfields defined by the Early Treatment of Diabetic Retinopathy Study. Cardiometabolic risk factors, including body mass index (BMI), hypertension, diabetes, lipid profiles, and smoking status, were assessed. Linear mixed regression analysis was conducted with consideration of familial correlations and adjustment for covariates. Age-, sex-, and axial length-adjusted analysis showed that systemic hypertension was associated with a significant change in macular thickness in most subfields except for the fovea. Compared with normotensive subjects, macular thickness was lower in subjects with systemic hypertension (P ≤ 0.05), with the highest difference (2.52%) in the outer temporal region and the lowest difference (1.44%) in the inner temporal region. This association persisted even after adjusting for other cardiometabolic risk factors. Other cardiometabolic risk factors were not independently associated with macular t...Continue Reading

Citations

Mar 24, 2017·Ophthalmic Epidemiology·Hassan HashemiAkbar Fotouhi
Jan 22, 2020·The British Journal of Ophthalmology·Sungsoon HwangYun-Mi Song
Mar 20, 2019·Sleep & Breathing = Schlaf & Atmung·Lorenzo Ferro DesideriSimone Ferrero
Mar 10, 2016·European Journal of Ophthalmology·Fahrettin AkaySalih Uzun
Nov 20, 2018·Acta Ophthalmologica·Muhammed ŞahinFatih Mehmet Türkcü
Sep 9, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ross T AitchisonUma Shahani
Jun 25, 2021·Korean Journal of Ophthalmology : KJO·Ismail Mohd-IlhamIsmail Shatriah
Dec 19, 2019·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Teruyo KidaTsunehiko Ikeda

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