Jun 29, 2011

Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Nobuyuki TakahashiToshio Shimada

Abstract

Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported. In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9. We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

  • References20
  • Citations8

References

Mentioned in this Paper

Genome-Wide Association Study
Pathogenic Aspects
HLA-DR2 Antigen
Pathogenesis
HLA Class I Histocompatibility Antigen, A-24 alpha Chain
Perfusion Magnetic Resonance Imaging
HLA Antigens
2D Echocardiography
Tomography, X-Ray Computerized Axial
Pathology

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