Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population.

Journal of Zhejiang University. Science. B
Qi YuPeng-hui Yang

Abstract

To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The literature search yielded 448 studies, in which 10 case-control studies including 1694 cases and 1456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the Chinese population.

References

Feb 13, 1990·Biochemistry·L B AgellonA R Tall
Jun 1, 1995·Circulation·P Libby
Aug 17, 2000·Current Opinion in Lipidology·A InazuH Mabuchi
Aug 17, 2001·Current Opinion in Lipidology·P J Barter, K A Rye
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Philip J BarterAlan R Tall

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Citations

Mar 7, 2014·Journal of Zhejiang University. Science. B·Jie DingXiao-gang Guo
Apr 4, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Iwona BojarIrena Walecka
Sep 5, 2018·Molecular Biology Reports·Joanna IwanickaIwona Żak

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